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Xu Xiao
Researcher at University of California, Los Angeles
Publications - 19
Citations - 760
Xu Xiao is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Sterol regulatory element-binding protein & Liver X receptor. The author has an hindex of 8, co-authored 15 publications receiving 502 citations. Previous affiliations of Xu Xiao include Chinese Academy of Sciences & Laboratory of Molecular Biology.
Papers
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Journal ArticleDOI
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling
Xu Xiao,Jing-Jie Tang,Chao Peng,Yan Wang,Lin Fu,Zhi-Ping Qiu,Yue Xiong,Lian-Fang Yang,Hai-Wei Cui,Xiao-Long He,Lei Yin,Wei Qi,Catherine C. L. Wong,Catherine C. L. Wong,Yun Zhao,Bo-Liang Li,Wen-Wei Qiu,Bao-Liang Song +17 more
TL;DR: The results of this study suggest that Hh signaling transduces to SMO through modulating its cholesterylation and provides a therapeutic opportunity to treat Hh-pathway-related cancers by targeting SMO cholesterolylation.
Journal ArticleDOI
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Jaspreet S. Sandhu,Shiqian Li,Shiqian Li,Louise Fairall,Simon G. Pfisterer,Simon G. Pfisterer,Jennifer E Gurnett,Xu Xiao,Thomas A. Weston,Dipti Vashi,Alessandra Ferrari,Jose L. Orozco,Celine L. Hartman,David Strugatsky,Stephen Lee,Cuiwen He,Cynthia Hong,Haibo Jiang,Laurent A. Bentolila,Alberto T. Gatta,Tim P. Levine,Annie Ferng,Richard T. Lee,David A. Ford,Stephen G. Young,Elina Ikonen,Elina Ikonen,John W.R. Schwabe,Peter Tontonoz +28 more
TL;DR: Three ER-resident proteins (Aster-A, -B, -C) that bind cholesterol and facilitate its removal from the plasma membrane are described to identify a nonvesicular pathway for plasma membrane to ER sterol trafficking in mammals.
Journal ArticleDOI
SREBP: a novel therapeutic target
Xu Xiao,Bao-Liang Song +1 more
TL;DR: These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.
Journal ArticleDOI
Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway
Lili Ding,Jinmei Li,Bao-Liang Song,Xu Xiao,Bin-Feng Zhang,Meng Qi,Wendong Huang,Li Yang,Zhengtao Wang +8 more
TL;DR: The inhibition of SREBP by curcumin decreased the biosynthesis of cholesterol and fatty acid and could be a potential leading compound for development of drugs for the prevention of obesity and insulin resistance.
Journal ArticleDOI
Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway.
Jinmei Li,Lili Ding,Bao-Liang Song,Xu Xiao,Meng Qi,Qiaoling Yang,Qiming Yang,Xiaowen Tang,Zhengtao Wang,Li Yang +9 more
TL;DR: It is demonstrated that emodin could improve high-fat diet-induced obesity and associated metabolic disturbances, and the underlying mechanism is probably associated with regulating SREBP pathway.