R
Rohitha SriRamaratnam
Researcher at Columbia University
Publications - 5
Citations - 3523
Rohitha SriRamaratnam is an academic researcher from Columbia University. The author has contributed to research in topics: Cell & Programmed cell death. The author has an hindex of 4, co-authored 4 publications receiving 1770 citations. Previous affiliations of Rohitha SriRamaratnam include Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
Patent
Oncogenic-RAS-signal dependent lethal compounds
TL;DR: In this paper, RAS-selective lethal compounds and compositions for cancer cell specific lethality are provided. And methods of screening for such compounds and methods of treating a condition in a mammal, by administering to the mammal a therapeutically effective amount of such compounds or compositions.
Journal ArticleDOI
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα
Chiara Borsari,Erhan Keles,Jacob A. McPhail,Alexander Schaefer,Rohitha SriRamaratnam,Wojciech Goch,Thorsten Schaefer,Martina De Pascale,Wojciech Bal,Matthias Gstaiger,John E. Burke,Matthias P. Wymann +11 more
TL;DR: A path to target solvent-exposed cysteines at a distance >10 Å from an ATP-site-directed core module and produce potent covalent phosphoinositide 3-kinase α (PI3Kα) inhibitors is delineated and generally suited to develop covalents tools targeting distal, unexplored Cys residues in biologically active enzymes.
Journal ArticleDOI
Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen.
Allan R. Shepard,Raymond E. Conrow,Iok-Hou Pang,Nasreen Jacobson,Mandana Rezwan,Katrin Rutschmann,Daniel Auerbach,Rohitha SriRamaratnam,Virginia W. Cornish +8 more
TL;DR: The identification of PDE6D as the molecular binding partner of AA provides insight into the role of this drug candidate in treating glaucoma.
Journal ArticleDOI
Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity
Hemant Varma,Nidhi M. Gangadhar,Reka R. Letso,Adam J. Wolpaw,Rohitha SriRamaratnam,Brent R. Stockwell,Brent R. Stockwell +6 more
TL;DR: The discovery of NID-1 identifies a previously unexplored cell death pathway, and modulating this pathway may have therapeutic applications, and these findings provide a proof-of-principle for using chemical screening to identify novel cell death paradigms.