L
Lars Fugger
Researcher at John Radcliffe Hospital
Publications - 187
Citations - 19108
Lars Fugger is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Epitope & Major histocompatibility complex. The author has an hindex of 61, co-authored 176 publications receiving 16759 citations. Previous affiliations of Lars Fugger include University of Oxford & Aarhus University Hospital.
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Journal ArticleDOI
Immunopathology of multiple sclerosis
TL;DR: The current understanding of multiple sclerosis immunopathology is discussed, long-standing hypotheses regarding the role of the immune system in the disease are evaluated, and key questions that are still unanswered are delineated.
Journal ArticleDOI
The Human Cell Atlas
Aviv Regev,Aviv Regev,Aviv Regev,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Eric S. Lander,Eric S. Lander,Eric S. Lander,Ido Amit,Christophe Benoist,Ewan Birney,Bernd Bodenmiller,Bernd Bodenmiller,Peter J. Campbell,Peter J. Campbell,Piero Carninci,Menna R. Clatworthy,Hans Clevers,Bart Deplancke,Ian Dunham,James Eberwine,Roland Eils,Roland Eils,Wolfgang Enard,Andrew Farmer,Lars Fugger,Berthold Göttgens,Nir Hacohen,Nir Hacohen,Muzlifah Haniffa,Martin Hemberg,Seung K. Kim,Paul Klenerman,Paul Klenerman,Arnold R. Kriegstein,Ed S. Lein,Sten Linnarsson,Emma Lundberg,Emma Lundberg,Joakim Lundeberg,Partha P. Majumder,John C. Marioni,John C. Marioni,John C. Marioni,Miriam Merad,Musa M. Mhlanga,Martijn C. Nawijn,Mihai G. Netea,Garry P. Nolan,Dana Pe'er,Anthony Phillipakis,Chris P. Ponting,Stephen R. Quake,Wolf Reik,Wolf Reik,Wolf Reik,Orit Rozenblatt-Rosen,Joshua R. Sanes,Rahul Satija,Ton N. Schumacher,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Ehud Shapiro,Padmanee Sharma,Jay W. Shin,Oliver Stegle,Michael R. Stratton,Michael J. T. Stubbington,Fabian J. Theis,Matthias Uhlen,Matthias Uhlen,Alexander van Oudenaarden,Allon Wagner,Fiona M. Watt,Jonathan S. Weissman,Barbara J. Wold,Ramnik J. Xavier,Nir Yosef,Nir Yosef,Human Cell Atlas Meeting Participants +81 more
TL;DR: An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.
Journal ArticleDOI
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
John S. Tzartos,Manuel A. Friese,Matthew Craner,Jackie Palace,Jia Newcombe,Margaret M. Esiri,Lars Fugger,Lars Fugger +7 more
TL;DR: Observations suggest an enrichment of both IL-17+CD4+ and CD8+ T cells in active MS lesions as well as an important role for IL- 17 in MS pathogenesis, with some remarkable differences from the experimental autoimmune encephalomyelitis model.
Journal ArticleDOI
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
TL;DR: The results indicate that the spontaneous response to β-cell antigens arises very early in life and that the anti-GAD immune response has a critical role in the disease process during this period.
Journal ArticleDOI
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
Heather L.E. Lang,Helle Jacobsen,Helle Jacobsen,Shinji Ikemizu,Christina Andersson,Christina Andersson,Karl Harlos,Lars S. Madsen,Peter Hjorth,Leif Søndergaard,Arne Svejgaard,Kai W. Wucherpfennig,David I. Stuart,John I. Bell,E. Yvonne Jones,Lars Fugger +15 more
TL;DR: It is demonstrated that a T cell receptor from an MS patient recognized both a DRB1-restricted myelin basic protein (MBP) and DRB5*0101-restricted Epstein-Barr virus (EBV) peptide, providing structural evidence for molecular mimicry involving HLA molecules.