R
Roland Stocker
Researcher at Victor Chang Cardiac Research Institute
Publications - 341
Citations - 36707
Roland Stocker is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Antioxidant & Lipid peroxidation. The author has an hindex of 92, co-authored 331 publications receiving 34364 citations. Previous affiliations of Roland Stocker include Australian National University & Chugai Pharmaceutical Co..
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Journal ArticleDOI
Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration
Ryan L. O'Hare Doig,Carole A. Bartlett,Ghassan J. Maghzal,Magdalena Lam,Michael Archer,Roland Stocker,Melinda Fitzgerald +6 more
TL;DR: In this article, partial dorsal transection of the optic nerve (ON) was used to model secondary degeneration in ventral nerve unaffected by the primary injury, and reactive species were assessed using fluorescent labeling and liquid chromatography/tandem mass spectroscopy (LC/MS/MS).
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Processes Involved in the Site-Specific Effect of Probucol on Atherosclerosis in Apolipoprotein E Gene Knockout Mice
Katherine Choy,Konstanze Beck,Francoise Y. Png,Ben J. Wu,Steven B. Leichtweis,Shane R. Thomas,Jing Y. Hou,Kevin D. Croft,Trevor A. Mori,Roland Stocker +9 more
TL;DR: Probucol affects atherosclerosis in apoE−/− mice independent of the accumulation of arterial lipid oxidation products, thereby dissociating the 2 processes and exerting antiinflammatory activity by decreasing accumulation of macrophages in lesions.
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Involvement of calcium, calmodulin and phospholipase A in the alteration of membrane dynamics and superoxide production of human neutrophils stimulated by phorbol myristate acetate
Roland Stocker,Richter Christoph +1 more
TL;DR: Evidence is presented that both the increased fluorescence polarization and the production of super‐oxide radicals by human neutrophils require calcium, calmodulin and phospholipase activity.
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Human blood cells support the reduction of low-density-lipoprotein-associated cholesteryl ester hydroperoxides by albumin-bound ebselen.
TL;DR: Test under which conditions ebselen can support reduction of LDLox-associated cholesteryl ester hydroperoxides outside cells demonstrate that, in the presence of blood cells, extracellular ebselsen is catalytically active, and suggest that eb Selen may be considered as a drug for extrace cellular targets.
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Heme moves to center stage in cerebral malaria.
Nicholas H. Hunt,Roland Stocker +1 more
TL;DR: In a mouse model of cerebral malaria, the enzyme heme oxygenase-1 or its product carbon monoxide can decrease free heme levels, offering a new therapeutic approach to this deadly complication.