R
Roland Stocker
Researcher at Victor Chang Cardiac Research Institute
Publications - 341
Citations - 36707
Roland Stocker is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Antioxidant & Lipid peroxidation. The author has an hindex of 92, co-authored 331 publications receiving 34364 citations. Previous affiliations of Roland Stocker include Australian National University & Chugai Pharmaceutical Co..
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Journal ArticleDOI
Antioxidant activity of albumin-bound bilirubin.
TL;DR: Results show that 1 mol of Alb-BR can scavenge 2 mol of peroxyl radicals and that small amounts of plasma bilirubin are sufficient to prevent oxidation of albumin-bound fatty acids as well as of the protein itself, indicating a role for Alb- BR as a physiological antioxidant in plasma and the extravascular space.
Journal ArticleDOI
Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein
Vincent W. Bowry,Roland Stocker +1 more
TL;DR: It is shown that α-TocH can be a strong prooxidant for the LDL itself, i.e., an aqueous dispersion of lipid-bearing particles in the form of alkylperoxyl radicals generated from a water-soluble azo initiator induced lipid peroxidation in LDL.
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Presence of hypochlorite-modified proteins in human atherosclerotic lesions.
TL;DR: Density centrifugation of plaque homogenates and Western blot analysis showed that, in the apo B-containing lipoprotein fraction, the mAb recognized protein(s) of molecular mass greater than apoB, similar to those produced during oxidation of LDL with HOCl in vitro.
Journal ArticleDOI
Clinical Relevance of Biomarkers of Oxidative Stress
Jeroen Frijhoff,Paul G. Winyard,Neven Zarkovic,Sean S. Davies,Roland Stocker,David Cheng,Annie R. Knight,Emma L. Taylor,Jeannette Oettrich,Tatjana Ruskovska,Ana Čipak Gašparović,Antonio Cuadrado,Daniela Weber,Henrik E. Poulsen,Tilman Grune,Harald H.H.W. Schmidt,Pietro Ghezzi +16 more
TL;DR: It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others, and the vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker.
Journal ArticleDOI
Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.
Jiri Neuzil,Roland Stocker +1 more
TL;DR: Results show that bilirubin inhibits oxidation of LDL lipids initiated within the lipoprotein core and indicate that this activity is mediated by interaction of the pigment with LDL's alpha-tocopherol.