Showing papers in "International Journal of Immunopharmacology in 1990"

TL;DR: It is demonstrated that SSG given by the oral route can activate peritoneal macrophages in mice.

TL;DR: Thymosin enhancement of PHA-induced high affinity IL-2R expression directly correlated with increased levels of Tac antigen expression, as determined by flow cytometry, and enhanced interleukin 2 (IL-2) production.

TL;DR: The results suggest that formosanin-C might display antitumor activity in association with modification of the immune system.

TL;DR: The effects of three quinolones were found to decrease extracellular TNF production in a dose-dependent manner at concentrations higher than 25 micrograms/ml as previously described by the laboratory with regard to IL-1 production.

TL;DR: The inhibition of apoptosis induced by ETP compounds by Zn2+ appears to be due to direct inhibition of oxidative damage to plasmid DNA in vitro by inhibiting auto-oxidation of the reduced ETP compound because of the looseness of the interaction.

TL;DR: Findings of inhibitory effects on other inflammatory mediators such as histamine, platelet-activating-factor (PAF) and interleukin 1 (IL-1) indicate that these plant alkaloids may be useful lead compounds for the development of a new class of anti-inflammatory drugs.

TL;DR: Recombinant tumour necrosis-alpha (TNF-alpha) curbed the growth of the bacilli in human macrophages in a reproducible fashion, highlighting the resistance of virulent mycobacteria against different mechanisms of cytokine-induced macrophage bactericidal activity.

TL;DR: It is shown that low -Mr constituents of an aqueous gel-extract inhibit the release of reactive oxygen species (ROS) by PMA-stimulated human PMN, and the inhibitory effect of the low-Mr compounds is the indirect result of the diminished availability of intracellular free Ca-ions.

TL;DR: Modifications have been made in the multiple assay model for assessing immunotoxicity in the rat that reduced the chance of non-specific stimulation of the immune system by Freund's adjuvant and eliminated possible antigen competition by using a single antigen to induce antibody synthesis and a DTH reaction.

TL;DR: Although FUT-175 is a potent inhibitor of C3a, C4a and C5a generation, it has novel and broad anti-inflammatory effects, possibly through actions in addition to complement inhibition as indicated by inhibition of FNLP-, LTB4- and ZAP-induced reactions.

TL;DR: The results of these experiments showed that adrenal corticosteroids are responsible for some but not all of the thymic involution due to ethanol intoxication, and this loss of cells from peripheral lymphoid organs such as the spleen and the decreased ability to respond to T-cell-dependent antigens is not influenced by adrenalectomy, indicating mechanisms other than cortICosteroids mediate these effects of ethanol.

TL;DR: The simultaneous injections of rMuIFN-γ and LPS at 6 h in advance could confer a good protection against the infection with the S. tryphimurium LT2 strain.

TL;DR: Results indicated that these agents have a selective immunosuppressive activity and did not exhibit immunostimulating activity in contrast to what has been reported for sodium artesunate.

TL;DR: It is concluded that THC and 11-OH THC inhibit T lymphocyte blastogenesis, however, unlike the THC mediated inhibition of natural killer cell activity, the process is not responsive to the cytokine interleukin 2.

TL;DR: NK- and monocyte-mediated cytotoxicity against K562 cells was further enhanced when the effector cells were primed with rIFN-gamma and were subsequently treated with cisplatin.

TL;DR: The results show that the dose response suppressive effect of THC on T-cell proliferation reflects a preferential inhibition of Ly2 vs L3T4 cells, and the effects on other functional parameters are in the process of investigation.

TL;DR: The effect of PAF antagonists on the growth of Ehrlich Ascites Tumor in vivo and the peritoneal macrophages for spreading ability and H2O2 release is analysed to understand the mechanism of this inhibition.

TL;DR: It is suggested that the sulfur content of schizophyllans is the most important factor for inhibiting growth of HIV, rather than molecular weight or kinds of sugar component.

TL;DR: The effects of oral administration of a hot water extract of Chlorella vulgaris (CVE) on the restoration of the leukocyte number and on the resistance against Escherichia coli infection were examined in cyclophosphamide (CY)-treated rats.

TL;DR: Results suggest that fluconazole may be less immunotoxic than itraconazole, and may be more suitable for use in immunocompromised patients.

TL;DR: Results showed that shosaiko-to is an IFN-alpha/beta inducer capable of repeated peroral administration and the activity induced by its peroral Administration did not decline during a long term treatment.

TL;DR: It has been revealed that patients who received the combined treatment postoperatively showed a lesser mortality and lower rate of recurrence, both reflecting significant increases in overall and relapse-free survivals as compared to those who received chemotherapy alone.

TL;DR: Combined administration of lentinan and IL-2 was found to augment the endogenous LAK activity even in the tumor bearer, and show a substantial inhibition of tumor growth and a significant increase in survival rate in the C3H/HeN/MM46 system.

TL;DR: The results support the efficiency or oral immunization in increasing local defenses, even at distance from the sensitized gut-associated lymphoid tissue, and provide evidence for the homing phenomenon in human mucosae associated lymphoids tissue (MALT).

TL;DR: It is shown that prolonged exposures to cholinergic compounds in vitro and in vivo modulate muscarinic receptor binding in lymphocytes as well as in brain tissue.

TL;DR: Results indicate that bryostatins activate T-cell through PK-C, and indicate that calcium mobilization is necessary for bryo 1 or PMA induced IL-2 gene expression.

TL;DR: It is suggested that while high concentrations of PAF suppress T cell proliferation, low concentrations selectively stimulate proliferation of the CD4+ subset, an effect which is partially counteracted by PAF-induced monocyte PGE2 production.

TL;DR: Data suggested that aldicarb may selectively suppress the stimulatory activity of macrophages by inhibiting IL-1 mediated signal to the T-cells without directly affecting theT-cell functions.

TL;DR: Effect of saikosaponin d was weaker than that of formalin-killed bacilli of Propionibacterium acnes and lipopolysaccharide and on enhancement of nonspecific resistance against L. monocytogenes was not seen.

TL;DR: Thymocytes from 15-day old C57BL/6 mice, pretreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) 4 days before sacrifice, showed an earlier response and a higher maximal cell proliferation than thymocyte from control mice upon stimulation by concanavalin A in vitro, in contrast to the conclusions from earlier published studies.