R
Roman G. Timoshchenko
Researcher at University of North Carolina at Chapel Hill
Publications - 10
Citations - 181
Roman G. Timoshchenko is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: G protein-coupled receptor kinase & Chemokine receptor. The author has an hindex of 6, co-authored 9 publications receiving 147 citations.
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Journal ArticleDOI
G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.
Matthew J. Billard,David J. Fitzhugh,Joel S. Parker,Jaime M. Brozowski,M.W. McGinnis,Roman G. Timoshchenko,D. Stephen Serafin,Ruth A. Lininger,Nancy Klauber-DeMore,G. Gary Sahagian,Young K. Truong,Maria F. Sassano,Jonathan S. Serody,Teresa K. Tarrant +13 more
TL;DR: It is demonstrated that alterations inGRK3 expression levels in tumor cells directly affect migration and invasion in vitro and the establishment of distant metastasis in vivo, and that GRK3 dysregulation may play an important part in TNBC metastasis.
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Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model.
Teresa K. Tarrant,Peng Liu,Rishi R. Rampersad,Denise Esserman,Lisa R. Rothlein,Roman G. Timoshchenko,M.W. McGinnis,David J. Fitzhugh,Dhavalkumar D. Patel,Dhavalkumar D. Patel,Alan M. Fong +10 more
TL;DR: The findings indicate that CX(3) CR1 deficiency is protective in inflammatory arthritis and may have effects that extend beyond migration that involve adaptive immune responses in autoimmune disease.
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G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses
Teresa K. Tarrant,Matthew J. Billard,Roman G. Timoshchenko,M.W. McGinnis,D. Stephen Serafin,Oded Foreman,Denise Esserman,Nelson J. Chao,William Lento,David Lee,David Lee,Dhavalkumar D. Patel,David P. Siderovski +12 more
TL;DR: It is concluded that the loss of GRK3‐mediated regulation of CXCL12/CXCR4 signaling contributes to some, but not all, of the complete WHIM phenotype and thatGRK3 inhibition may be beneficial in the treatment of inflammatory arthritis.
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G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.
Patrick M. Giguère,Matthew J. Billard,Geneviève Laroche,Brian K. Buckley,Roman G. Timoshchenko,M.W. McGinnis,Denise Esserman,Oded Foreman,Peng Liu,David P. Siderovski,Teresa K. Tarrant +10 more
TL;DR: The results suggest that GPSM3 is an important regulator of monocyte function involving mechanisms of differentiation, survival, and chemotaxis, and deficiency in GPSM 3 expression is protective in acute inflammatory arthritis.
Journal ArticleDOI
Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer
Gina Song,Teresa K. Tarrant,Taylor F. White,David A. Barrow,Charlene M. Santos,Roman G. Timoshchenko,Suzan K. Hanna,Ramesh K. Ramanathan,Craig R. Lee,Victoria L. Bae-Jump,Paola A. Gehrig,William C. Zamboni +11 more
TL;DR: The authors showed the important role the immune system played and would enable better designs of future drug delivery systems and emphasize that the interplay between PLD and chemokines may have an important role in optimizing PLD therapy.