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Ronald M. Lechan

Researcher at Tufts Medical Center

Publications -  225
Citations -  14024

Ronald M. Lechan is an academic researcher from Tufts Medical Center. The author has contributed to research in topics: Hypothalamus & Thyrotropin-releasing hormone. The author has an hindex of 65, co-authored 218 publications receiving 13317 citations. Previous affiliations of Ronald M. Lechan include Mount Desert Island Biological Laboratory & University of Bologna.

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Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

Maribel Rios, +8 more
- 01 Oct 2001 - 
TL;DR: This work has generated conditional mutants in which brain-derived neurotrophic factor has been eliminated from the brain after birth through the use of the cre-loxP recombination system, and these mutants were hyperactive after exposure to stressors and had higher levels of anxiety when evaluated in the light/dark exploration test.
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Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus.

Gábor Légrádi, +5 more
- 01 Jun 1997 - 
TL;DR: Fasted animals showed significant reduction in plasma total and free T4 and T3 levels compared with controls, that were restored toward normal by the administration of leptin, and the possibility that leptin may have an important role in the neuroendocrine regulation of the thyroid axis was raised.
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Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan, +6 more
- 23 Apr 1990 - 
TL;DR: It is demonstrated that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.
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Thyroid Hormone Regulates TRH Biosynthesis in the Paraventricular Nucleus of the Rat Hypothalamus

Thomas P. Segerson, +6 more
- 02 Oct 1987 - 
TL;DR: A nearly twofold increase in proTRH mRNA was observed in hypothyroid animals; this increase could be obliterated by levothyroxine treatment, suggesting an inverse relation between circulating thyroid hormone and pro TRH mRNA.
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Thyrotropin-releasing hormone precursor: characterization in rat brain

Ronald M. Lechan, +6 more
- 10 Jan 1986 - 
TL;DR: Findings indicate that mammalian TRH arises by posttranslational processing of a larger precursor protein, and the ability of the TRH prohormone to generate multiple copies of the bioactive peptide may be an important mechanism in the amplification of hormone production.