R
Rongbiao Pi
Researcher at Sun Yat-sen University
Publications - 115
Citations - 3954
Rongbiao Pi is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Neuroprotection & Oxidative stress. The author has an hindex of 35, co-authored 108 publications receiving 3302 citations. Previous affiliations of Rongbiao Pi include Hong Kong University of Science and Technology.
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Journal ArticleDOI
Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.
TL;DR: Evidence is provided that tan protects cardiac myocytes against oxidative stress-induced apoptosis and is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio.
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Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways.
Rongbiao Pi,Wenming Li,Nelson T.K. Lee,Hugh H. Chan,Yongmei Pu,Ling Nga Chan,Nikolaus J. Sucher,Donald C. Chang,Mingtao Li,Yifan Han +9 more
TL;DR: It is demonstrated that minocycline prevents glutamate‐induced apoptosis in CGNs by directly inhibiting p38 activity and maintaining the activation of PI3‐K/Akt pathway, which offers a novel modality as to how the drug exerts protective effects.
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Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
TL;DR: The results suggest that these irons cause differential effects on the expression of APP and BACE1 in PC12 cells, and curcumin can significantly reverse their effects.
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Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors
Wenming Li,Rongbiao Pi,Hugh H. Chan,Hongjun Fu,Nelson T.K. Lee,Hing Wai Tsang,Yongmei Pu,Donald C. Chang,Chaoying Li,Chaoying Li,Jialie Luo,Keming Xiong,Zhi-Wang Li,Hong Xue,Paul R. Carlier,Yuan Ping Pang,Karl Wah Keung Tsim,Mingtao Li,Yifan Han +18 more
TL;DR: It is suggested that bis(7)-tacrine prevents glutamate-induced neuronal apoptosis through directly blocking NMDA receptors at the MK-801-binding site, which offers a new and clinically significant modality as to how the agent exerts neuroprotective effects.
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Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.
Rongbiao Pi,Xuexuan Mao,Xiaojuan Chao,Zhiyi Cheng,Mengfei Liu,Xiaolu Duan,Mingzhong Ye,Xiaohong Chen,Zhengrong Mei,Peiqing Liu,Wenming Li,Wenming Li,Yifan Han +12 more
TL;DR: It is reported for the first time that tacrine-6-ferulic acid (T6FA), one of these compounds, can prevent amyloid-β peptide (Aβ)-induced AD-associated pathological changes in vitro and in vivo.