Rosa Carnuccio

TL;DR: Evidence is provided of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53, which improved the survival of p 53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels.

TL;DR: It is reported that Macrocortin derived from rat peritoneal leukocytes is an intracellular polypeptide whose release and synthesis are stimulated by steroids.

TL;DR: Part of the anti-inflammatory and immunosuppressive actions of glucocorticoids is due to their inhibition of the induction of the NO synthase, which is suggested to be responsible for the release of NO.

TL;DR: The present study shows that macrolide antibiotics have anti-inflammatory activity, which likely depends on their ability to prevent the production of proinflammatory mediators and cytokines, and suggests that these agents, particularly roxithromycin, can exert therapeutic effects independently of their antibacterial activity.

TL;DR: The current state-of-the art suggests a complex relationship between cancer and deregulated autophagy that must be disentangled by further in-depth investigation.