R
Rosalia Bertorelli
Researcher at Istituto Italiano di Tecnologia
Publications - 113
Citations - 5455
Rosalia Bertorelli is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Receptor & Acetylcholine. The author has an hindex of 38, co-authored 105 publications receiving 4734 citations. Previous affiliations of Rosalia Bertorelli include Merck & Co. & Stockholm University.
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Journal ArticleDOI
CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms
Massimiliano Beltramo,N. Bernardini,Rosalia Bertorelli,Marilena Campanella,Elisa Nicolussi,Silva Fredduzzi,Angelo Reggiani +6 more
TL;DR: It is suggested that CB2 agonists may elicit their analgesic effect by acting not only at non‐neuronal peripheral sites but also at neural level, making CB2 an attractive target for chronic pain treatment.
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Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice.
Malika El Yacoubi,Catherine Ledent,Marc Parmentier,Rosalia Bertorelli,Ennio Ongini,Jean Costentin,Jean-Marie Vaugeois +6 more
TL;DR: The hypothesis that blockade of the adenosine A2A receptor might be an interesting target for the development of effective antidepressant agents is supported.
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Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis.
TL;DR: The intracerebroventricular injection of hemicholinium-3 caused a marked decrease in acetylcholine release from the striata of 2- and 18-month-old rats, but there was no age-related difference between the young and old rats, indicating that the differences observed were due to the lower basal release found in the old rats.
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A catalytically silent FAAH-1 variant drives anandamide transport in neurons
Jin Fu,Giovanni Bottegoni,Oscar Sasso,Rosalia Bertorelli,Walter Rocchia,Matteo Masetti,Ana Guijarro,Alessio Lodola,Andrea Armirotti,Gianpiero Garau,Tiziano Bandiera,Angelo Reggiani,Marco Mor,Andrea Cavalli,Andrea Cavalli,Daniele Piomelli,Daniele Piomelli +16 more
TL;DR: A partly cytosolic variant of the intracellular anandamide-degrading enzyme fatty acid amide hydrolase-1 (FAAH-1), termed FAAH-like an andamide transporter (FLAT), that lacked amidase activity but bound anandamon with low micromolar affinity and facilitated its translocation into cells is described.
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The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.
Geoffrey B. Varty,Mariagrazia Grilli,Angelo Forlani,Silva Fredduzzi,Michael Grzelak,Donald H. Guthrie,Robert A. Hodgson,Sherry X. Lu,Elisa Nicolussi,Pond Annamarie,Eric M. Parker,John C. Hunter,Guy A. Higgins,Angelo Reggiani,Rosalia Bertorelli +14 more
TL;DR: Findings support the potential utility of mGLUR5 and mGluR1 antagonists for both the treatment of chronic pain and as novel anxiolytics in models of pain and anxiety.