Silvana Consolo

TL;DR: The striatum is viewed as a structure performing fast neurotransmitter-mediated operations through somatotopically organized projections to medium-size spiny neurons, contrasted with another view that depicts the striatum as a site of diffuse modulatory influences mediated by cholinergic interneurons and by dopamine and N-methyl-D-aspartate receptors.

TL;DR: It was shown that galanin, in a concentration-dependent manner, inhibited the evoked release of acetylcholine in the ventral, but not in the dorsal, hippocampus of the rat, suggesting that a large proportion of them is localized on cholinergic nerve terminals of septal afferents.

TL;DR: The intracerebroventricular injection of hemicholinium-3 caused a marked decrease in acetylcholine release from the striata of 2- and 18-month-old rats, but there was no age-related difference between the young and old rats, indicating that the differences observed were due to the lower basal release found in the old rats.

TL;DR: The results of work carried out mainly in rats under different experimental conditions indicate that the d- and l-isomers of fenfluramine are metabolized in different ways, and the two isomers show differentpharmacological and neuro-chemical activity.

TL;DR: The results provide the first evidence that serotonin facilitates ACh release in frontal cortex through stimulation of 5-HT4 receptors which are not tonically activated, and 5- HT4 receptor agonists might offer a novel means of boosting central cholinergic function to overcome theCholinergic deficit in memory disorders.