R
Rose McGlauflin
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 3
Citations - 412
Rose McGlauflin is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Mitochondrion & FGF21. The author has an hindex of 3, co-authored 3 publications receiving 243 citations. Previous affiliations of Rose McGlauflin include University of Iowa.
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Journal ArticleDOI
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.
Kensuke Tsushima,Heiko Bugger,Adam R. Wende,Jamie Soto,Gregory A. Jenson,Austin R. Tor,Rose McGlauflin,Helena Kenny,Yuan Zhang,Rhonda Souvenir,Xiao X. Hu,Crystal Sloan,Renata O. Pereira,Vitor A. Lira,Kenneth W. Spitzer,Terry L. Sharp,Kooresh I. Shoghi,Genevieve C. Sparagna,Eva A. Rog-Zielinska,Peter Kohl,Oleh Khalimonchuk,Oleh Khalimonchuk,Jean E. Schaffer,E. Dale Abel +23 more
TL;DR: The results reveal a molecular mechanism by which lipid overload-induced mitochondrial ROS generation causes mitochondrial dysfunction by inducing post-translational modifications of mitochondrial proteins that regulate mitochondrial dynamics.
Journal ArticleDOI
OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance
Renata O. Pereira,Satya Murthy Tadinada,Frederick M Zasadny,Karen Jesus Oliveira,Karla Maria Pereira Pires,Angela Crystal Olvera,Jennifer Jeffers,Rhonda Souvenir,Rose McGlauflin,Alec W. Seei,Trevor Funari,Hiromi Sesaki,Matthew J. Potthoff,Christopher M. Adams,Ethan J Anderson,Ethan J Anderson,E. Dale Abel,E. Dale Abel +17 more
TL;DR: In this article, the role of the mitochondrial fusion protein optic atrophy 1 (OPA1) in differentiated skeletal muscle by reducing OPA1 gene expression in an inducible manner was examined.
Journal ArticleDOI
Mitochondrial pyruvate carriers are required for myocardial stress adaptation.
Yuan Zhang,Paul V. Taufalele,Jesse D. Cochran,Isabelle Robillard-Frayne,Jonas Maximilian Marx,Jonas Maximilian Marx,Jamie Soto,Adam J. Rauckhorst,Fariba Tayyari,Alvin D. Pewa,Lawrence R. Gray,Lynn M. Teesch,Patrycja Puchalska,Patrycja Puchalska,Trevor Funari,Rose McGlauflin,Kathy Zimmerman,William J. Kutschke,Thomas Cassier,Shannon Hitchcock,Kevin D. Lin,Kevin M. Kato,Jennifer L. Stueve,Lauren Haff,Robert M. Weiss,James E. Cox,Jared Rutter,Jared Rutter,Eric B. Taylor,Peter A. Crawford,Peter A. Crawford,E. Douglas Lewandowski,E. Douglas Lewandowski,Christine Des Rosiers,E. Dale Abel +34 more
TL;DR: It is shown that MPC-mediated mitochondrial pyruvate utilization is essential for the partitioning of glucose-derived cytosolic metabolic intermediates, which modulate myocardial stress adaptation and highlight the centrality of pyruVate metabolism to myocardian metabolism and function.