J
Jared Rutter
Researcher at University of Utah
Publications - 161
Citations - 10678
Jared Rutter is an academic researcher from University of Utah. The author has contributed to research in topics: Mitochondrion & Citric acid cycle. The author has an hindex of 45, co-authored 143 publications receiving 8663 citations. Previous affiliations of Jared Rutter include Huntsman Cancer Institute & Howard Hughes Medical Institute.
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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.
TL;DR: The reduced forms of the redox cofactors, NAD(H) and NADP(H), strongly enhance DNA binding of the Clock:BMal1 and NPAS2:BMAL1 heterodimers, whereas the oxidized forms inhibit, raising the possibility that food, neuronal activity, or both may entrain the circadian clock by direct modulation of cellular redox state.
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A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Daniel K. Bricker,Eric B. Taylor,John C. Schell,Thomas Orsak,Audrey Boutron,Yu-Chan Chen,James E. Cox,Caleb M. Cardon,Jonathan G. Van Vranken,Noah Dephoure,Claire Redin,Sihem Boudina,Steven P. Gygi,Michèle Brivet,Carl S. Thummel,Jared Rutter +15 more
TL;DR: Human genetic studies of three families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1, changing single amino acids that are conserved throughout eukaryotes, demonstrating that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier.
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SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Huai Xiang Hao,Oleh Khalimonchuk,Margit Schraders,Noah Dephoure,Jean-Pierre Bayley,Henricus P. M. Kunst,Peter Devilee,Cor W. R. J. Cremers,Joshua D. Schiffman,Brandon G. Bentz,Steven P. Gygi,Dennis R. Winge,Hannie Kremer,Jared Rutter +13 more
TL;DR: A combination of bioinformatics, yeast genetics, biochemistry, and human genetics was used to show that a previously uncharacterized mitochondrial protein (Sdh5) is required for the activity of respiratory complex II, leading to the discovery of a human tumor susceptibility gene.
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Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
Chendong Yang,Bookyung Ko,Christopher T. Hensley,Lei Jiang,Ajla T. Wasti,Jiyeon Kim,Jessica Sudderth,MariaAntonietta Calvaruso,Lloyd Lumata,Matthew A. Mitsche,Jared Rutter,Matthew E. Merritt,Ralph J. DeBerardinis +12 more
TL;DR: This work shows that import of pyruvate into the mitochondria suppresses GDH and glutamine-dependent acetyl-CoA formation and defines a mechanism to induce glutaminolysis and uncover a survival pathway engaged during compromised supply of pyRuvate to the mitochondaria.
Journal ArticleDOI
NPAS2: A Gas-Responsive Transcription Factor
Elhadji M. Dioum,Jared Rutter,Jason R. Tuckerman,Gonzalo Gonzalez,Marie Alda Gilles-Gonzalez,Steven L. McKnight +5 more
TL;DR: Results indicate that the heterodimerization of NPAS2, and presumably the expression of its target genes, are regulated by a gas through the heme-based sensor described here.