R
Rosemary Oh
Researcher at University of British Columbia
Publications - 3
Citations - 940
Rosemary Oh is an academic researcher from University of British Columbia. The author has contributed to research in topics: Chromosome 7 (human) & Internalization. The author has an hindex of 3, co-authored 3 publications receiving 882 citations.
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Journal ArticleDOI
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
Elizabeth J. Slow,Jeremy M. Van Raamsdonk,Daniel A. Rogers,Sarah H. Coleman,Rona K. Graham,Yu Deng,Rosemary Oh,Nagat Bissada,Sazzad M. Hossain,Yu-Zhou Yang,Xiao-Jiang Li,Elizabeth M. Simpson,Claire-Anne Gutekunst,Blair R. Leavitt,Michael R. Hayden +14 more
TL;DR: The natural history of HD-related changes in the YAC128 mice has been defined, demonstrating the presence of huntingtin inclusions after the onset of behavior and neuropathological changes and making it an ideal mouse model for the assessment of neuroprotective and other therapeutic interventions.
Journal ArticleDOI
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
Martina Metzler,Bo Li,Lu Gan,John Georgiou,Claire-Anne Gutekunst,Yushan Wang,Enrique Torre,Rebecca S. Devon,Rosemary Oh,Valerie Legendre-Guillemin,Mark M. Rich,Christine M. Alvarez,Marina Gertsenstein,Peter S. McPherson,Andras Nagy,Yu Tian Wang,John C. Roder,Lynn A. Raymond,Michael R. Hayden +18 more
TL;DR: A profound dose‐dependent defect in clathrin‐mediated internalization of GluR1‐containing AMPA receptors was observed in neurons from HIP1−/− mice, providing strong evidence that HIP1 regulates AMPA receptor trafficking in the central nervous system through its function in clathan‐mediated endocytosis.
Journal ArticleDOI
Epigenetic and Phenotypic Consequences of a Truncation Disrupting the Imprinted Domain on Distal Mouse Chromosome 7
Rosemary Oh,Rita Ho,Lynn Mar,Marina Gertsenstein,Jana Paderova,John Hsien,Jeremy A. Squire,Jeremy A. Squire,Michael J. Higgins,Andras Nagy,Louis Lefebvre +10 more
TL;DR: All the imprinted genes located in the region and required for normal development are silenced by an IC2-dependent mechanism on the paternal allele, and the developmental phenotype of maternal heterozygotes is rescued fully by a paternally inherited deletion of IC2.