Rosette Goïame

TL;DR: A link between differential centrosome maturation and Notch signaling is uncovered and an unexpected compensatory mechanism involving the Golgi apparatus in restoring symmetry in proliferative divisions is revealed.

TL;DR: This work shows that Notch signaling, which is classically associated with an undifferentiated state, remains active in prospective neurons until they delaminate, and provides evidence that the Notch ligand Delta-like 1 (Dll1) promotes differentiation by reducing NotCh signaling through a Cis-inhibition mechanism.

TL;DR: In this paper, a collection of fluorogenic chromophores with various electronic properties enables to generate bimolecular fluorescent assemblies that cover the visible spectrum from blue to red using a single protein tag engineered and optimized by directed evolution and rational design.

TL;DR: It is shown that AGS3 is not required for planar divisions of neural progenitors in the mouse neocortex and Drosophila Pins is unable to substitute for LGN loss of function in vertebrates, highlighting that species‐specific modulations of the interactions between components of the Pins/LGN complex are crucial in vivo for spindle orientation.

TL;DR: It is shown that CAPZB controls spindle orientation independently of its classical role in the actin cytoskeleton by regulating the assembly, stability, and motor activity of the dynein/dynactin complex at the cell cortex, as well as the dynamics of mitotic microtubules.