Roy O. Weller

TL;DR: Therapeutic strategies that improve elimination of Abeta and other soluble metabolites from the brain may prevent cognitive decline in Alzheimer's disease.

TL;DR: It is concluded that the presence of ubiquitin-IR inclusions in lower motor neurons represents a characteristic pathological feature of ALS in its various clinical forms.

TL;DR: The role of the vasculature and the impact of vascular pathology on the peri- and para-vascular clearance pathways of the brain are reviewed and the different views on the possible routes for ISF drainage of thebrain are discussed in the context of pathological significance.

TL;DR: The hypothesis that perivascular solute drainage from the brain is altered both in the ageing brain and as a consequence of CAA is supported, which has implications for the success of therapeutic strategies for the treatment of AD that rely upon the health of the ageing cerebral vasculature.

TL;DR: The findings are consistent with the hypothesis that Abeta immunization results in solubilization of plaque Abeta42 which, at least in part, exits the brain via the perivascular pathway, causing a transient increase in the severity of CAA.