R
Ru-ching Hsia
Researcher at University of Maryland, College Park
Publications - 24
Citations - 1096
Ru-ching Hsia is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Chlamydia trachomatis & Medicine. The author has an hindex of 13, co-authored 20 publications receiving 1005 citations. Previous affiliations of Ru-ching Hsia include University of Maryland, Baltimore.
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Journal ArticleDOI
Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche‐specific genes in the evolution of the Chlamydiaceae
Timothy D. Read,Garry S. A. Myers,Robert C. Brunham,William C. Nelson,Ian T. Paulsen,Ian T. Paulsen,John F. Heidelberg,Erik Holtzapple,Hoda Khouri,N. B. Federova,Heather A. Carty,Lowell Umayam,Daniel H. Haft,Jeremy Peterson,Maureen J. Beanan,Owen White,Steven L. Salzberg,Ru-ching Hsia,G. McClarty,Roger G. Rank,Patrik M. Bavoil,Claire M. Fraser,Claire M. Fraser +22 more
TL;DR: The genome of C.caviae was determined, representing the fourth species with a complete genome sequence from the Chlamydiaceae family of obligate intracellular bacterial pathogens, and enabling dissection of the roles played by niche-specific genes in these important bacterial pathogens.
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Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen
Deborah D. Crane,John H. Carlson,Elizabeth R. Fischer,Patrik M. Bavoil,Ru-ching Hsia,Chun Tan,Cho-Chou Kuo,Harlan D. Caldwell +7 more
TL;DR: It is reported that all C. trachomatis reference serotypes responsible for sexually transmitted disease and blinding trachoma synthesize a highly conserved surface-exposed antigen termed polymorphic membrane protein D (PmpD), and it is shown that Ab specific to PmpD are neutralizing in vitro.
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Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
TL;DR: It is reported that recycling endosomes are essential for externalization of cytoplasmic secretory protein tissue transglutaminase (tTG), and the unconventional mechanism of tTG secretion is unraveled, indicating involvement of endosomal trafficking in non-classical protein secretion.
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Isolation of a New Chlamydia species from the Feral Sacred Ibis (Threskiornis aethiopicus): Chlamydia ibidis.
Fabien Vorimore,Ru-ching Hsia,Heather Huot-Creasy,Suzanne Bastian,Suzanne Bastian,Lucie Deruyter,Anne Passet,Konrad Sachse,Patrik M. Bavoil,Garry S. A. Myers,Karine Laroucau +10 more
TL;DR: Ulastructural analysis, comparative sequence analysis, and determination of the whole genome sequence confirmed the relatedness of the new isolate to members of the Chlamydiaceae, while, at the same time demonstrating a unique position outside the currently recognized species of this family.
Journal ArticleDOI
Chlamydia trachomatis-Infected Patients Display Variable Antibody Profiles against the Nine-Member Polymorphic Membrane Protein Family
Chun Tan,Ru-ching Hsia,Huizhong Shou,Catherine L. Haggerty,Roberta B. Ness,Charlotte A. Gaydos,Deborah Dean,Amy M. Scurlock,David Wilson,Patrik M. Bavoil +9 more
TL;DR: The results indicate that the Pmps elicit various serologic responses in C. trachomatis-infected patients and are consistent with the pmp gene family being the basis of a mechanism of antigenic variation.