R
Ru Feng
Researcher at Albert Einstein College of Medicine
Publications - 14
Citations - 1387
Ru Feng is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications receiving 1263 citations.
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Journal ArticleDOI
Stepwise Reprogramming of B Cells into Macrophages
TL;DR: Observations indicate that C/EBPalpha and beta remodel the transcription network of B cells into that of macrophages through a series of parallel and sequential changes that require endogenous PU.1.
Journal ArticleDOI
PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells
Ru Feng,Sabrina C. Desbordes,Huafeng Xie,Ester Sanchez Tillo,Fiona J. Pixley,E. Richard Stanley,Thomas Graf,Thomas Graf +7 more
TL;DR: The data suggest that it might become possible to induce the transdifferentiation of skin-derived fibroblasts into cell types desirable for tissue regeneration, and the effects of PU.1 and C/EBPα on fibro Blasts are examined.
Journal ArticleDOI
Zanubrutinib in relapsed/refractory mantle cell lymphoma: long-term efficacy and safety results from a phase 2 study
Yuqin Song,Keshu Zhou,Dehui Zou,Jianfeng Zhou,Jianda Hu,Haiyan Yang,Huilai Zhang,Jie Jin,Wei Xu,Fangfang Lv,Ru Feng,Sujun Gao,Haiyi Guo,Lei Zhou,Jian Huang,William Novotny,Pil Kim,Yiling Yu,Binghao Wu,Jun Zhu +19 more
TL;DR: Outcomes of a phase 2 study of zanubrutinib therapy for 86 patients with relapsed/refractory MCL were promising, with an overall response, a complete response rate of 77.9%, and no new safety concerns.
Journal ArticleDOI
Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition
Jing Li,Yingyi Ye,Zhihan Liu,Guo-Yang Zhang,Huiqi Dai,Jiaqian Li,Boxuan Zhou,Yihong Li,Qiyi Zhao,Jin-Tao Huang,Jingwei Feng,Shu Liu,Peigang Ruan,Jin-Jing Wang,Jiang-pei Liu,Mingdong Huang,Xinwei Liu,Shubin Yu,Ziyang Liang,Liping Ma,Xiaoxia Gou,Guoliang Zhang,Nian Chen,Yiwen Lu,Can Di,Qidong Xia,Jia-Dong Pan,Ru Feng,Qingqing Cai,Shicheng Su +29 more
TL;DR: It is demonstrated that mitochondrial fission in macrophages induced by multiple antibodies is essential for phagocytosis of live tumor cells and that GFPT2 is identified as a potential target to improve antibody therapy.
Journal ArticleDOI
Zanubrutinib Monotherapy for Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Pooled Analysis of Three Studies
Wei Xu,Shenmiao Yang,Constantine S. Tam,John F. Seymour,Keshu Zhou,Stephen Opat,Lugui Qiu,Mingyuan Sun,Tingyu Wang,Judith Trotman,Ling Pan,Sujun Gao,Jian Feng Zhou,Daobin Zhou,Jun Zhu,Yuqin Song,Jianda Hu,Ru Feng,Haiwen Huang,Dan Su,Miao Shi,Jianyong Li +21 more
TL;DR: With extended follow-up, zanubrutinib yielded long-term benefits and demonstrated a favorable safety profile for patients with TN or RR CLL/SLL.