Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Oded Shaham,Ru Wei,Thomas J. Wang,Thomas J. Wang,Catherine Ricciardi,Gregory D. Lewis,Gregory D. Lewis,Ramachandran S. Vasan,Steven A. Carr,Ravi Thadhani,Ravi Thadhani,Robert E. Gerszten,Robert E. Gerszten,Vamsi K. Mootha,Vamsi K. Mootha +14 more
TLDR
A mass spectrometry‐based strategy to simultaneously measure 191 metabolites following glucose ingestion laid the groundwork for using metabolic profiling to define an individual's ‘insulin response profile’, which could have value in predicting diabetes, its complications, and in guiding therapy.Abstract:
Bioinformatics and Integrative Genomics Award from National Human Genome Research Institute; National Institutes of Health (R01-HL-086875, R01-HL-083197); Heart Failure Society of America and the Harvard/MIT Clinical Investigator Training Program; National Institutes of Health (U01HL083141); Donald W Reynolds Foundation and Fondation Leducq; Burroughs Wellcome Career Award in the Biomedical Sciences; Howard Hughes Medical Institute Early Career Physician Scientist Award; Broad Institute Scientific Planning and Allocation of Resources Committee; National Institutes of Health (General Clinical Research Center grant); General Clinical Research Center (MO1-RR01066); National Institutes of Health/National Heart Lung and Blood Institute (N01-HC-25195).read more
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Metabolite profiles and the risk of developing diabetes
Thomas J. Wang,Martin G. Larson,Martin G. Larson,Ramachandran S. Vasan,Ramachandran S. Vasan,Susan Cheng,Susan Cheng,Susan Cheng,Eugene P. Rhee,Eugene P. Rhee,Elizabeth L. McCabe,Elizabeth L. McCabe,Gregory D. Lewis,Gregory D. Lewis,Caroline S. Fox,Caroline S. Fox,Paul F. Jacques,Céline Fernandez,Christopher J. O'Donnell,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen A Carr,Vamsi K. Mootha,Vamsi K. Mootha,Jose C. Florez,Jose C. Florez,Amanda Souza,Olle Melander,Clary B. Clish,Robert E. Gerszten,Robert E. Gerszten +30 more
TL;DR: Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Journal ArticleDOI
Innovation: Metabolomics: the apogee of the omics trilogy
TL;DR: By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and are shaping the understanding of cell biology, physiology and medicine.
Journal ArticleDOI
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris,Benjamin F. Voight,Benjamin F. Voight,Tanya M. Teslovich,Teresa Ferreira,Ayellet V. Segrè,Ayellet V. Segrè,Valgerdur Steinthorsdottir,Rona J. Strawbridge,Hassan Khan,Harald Grallert,Anubha Mahajan,Inga Prokopenko,Hyun Min Kang,Christian Dina,Tõnu Esko,Ross M. Fraser,Stavroula Kanoni,Ashok Kumar,Vasiliki Lagou,Claudia Langenberg,Jian'an Luan,Cecilia M. Lindgren,Martina Müller-Nurasyid,Sonali Pechlivanis,N. William Rayner,Laura J. Scott,S Wiltshire,Loic Yengo,Leena Kinnunen,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Soumya Raychaudhuri,Soumya Raychaudhuri,Andrew D. Johnson,Antigone S. Dimas,Antigone S. Dimas,Antigone S. Dimas,Ruth J. F. Loos,Sailaja Vedantam,Sailaja Vedantam,Han Chen,Jose C. Florez,Jose C. Florez,Caroline S. Fox,Caroline S. Fox,Ching-Ti Liu,Denis Rybin,David Couper,Wen Hong L. Kao,Man Li,Marilyn C. Cornelis,Peter Kraft,Qi Sun,Rob M. van Dam,Rob M. van Dam,Heather M. Stringham,Peter S. Chines,Krista Fischer,Pierre Fontanillas,Oddgeir L. Holmen,Sarah E. Hunt,Anne U. Jackson,Augustine Kong,Robert W. Lawrence,Julia Meyer,John R. B. Perry,John R. B. Perry,Carl G. P. Platou,Simon C. Potter,Emil Rehnberg,Neil Robertson,Suthesh Sivapalaratnam,Alena Stančáková,Kathleen Stirrups,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Andrew R. Wood,Peter Almgren,Mustafa Atalay,Rafn Benediktsson,Lori L. Bonnycastle,Noël P. Burtt,Jason Carey,Guillaume Charpentier,Andrew Crenshaw,Alex S. F. Doney,Mozhgan Dorkhan,Sarah Edkins,Valur Emilsson,Elodie Eury,Tom Forsén,Karl Gertow,Bruna Gigante,George B. Grant,Christopher J. Groves,Candace Guiducci,Christian Herder,Astradur B. Hreidarsson,Jennie Hui,Jennie Hui,Alan James,Alan James,Anna Jonsson,Wolfgang Rathmann,Norman Klopp,Jasmina Kravic,Kaarel Krjutškov,Cordelia Langford,Karin Leander,Eero Lindholm,Stéphane Lobbens,Satu Männistö,Ghazala Mirza,Thomas W. Mühleisen,Bill Musk,Bill Musk,Melissa Parkin,Loukianos S. Rallidis,Jouko Saramies,Bengt Sennblad,Sonia Shah,Gunnar Sigurðsson,Angela Silveira,Gerald Steinbach,Barbara Thorand,Joseph Trakalo,Fabrizio Veglia,Roman Wennauer,Wendy Winckler,Delilah Zabaneh,Harry Campbell,Cornelia M. van Duijn,André G. Uitterlinden,Albert Hofman,Eric J.G. Sijbrands,Gonçalo R. Abecasis,Katharine R. Owen,Eleftheria Zeggini,Mieke D. Trip,Nita G. Forouhi,Ann-Christine Syvänen,Johan G. Eriksson,Johan G. Eriksson,Leena Peltonen,Markus M. Nöthen,Beverley Balkau,Colin N. A. Palmer,Valeriya Lyssenko,Tiinamaija Tuomi,Bo Isomaa,David J. Hunter,Lu Qi,Alan R. Shuldiner,Alan R. Shuldiner,Michael Roden,Inês Barroso,Tom Wilsgaard,John Beilby,John Beilby,Kees Hovingh,Jackie F. Price,James F. Wilson,Rainer Rauramaa,Timo A. Lakka,Lars Lind,George Dedoussis,Inger Njølstad,Nancy L. Pedersen,Kay-Tee Khaw,Nicholas J. Wareham,Sirkka Keinänen-Kiukaanniemi,Timo Saaristo,Eeva Korpi-Hyövälti,Juha Saltevo,Markku Laakso,Johanna Kuusisto,Andres Metspalu,Francis S. Collins,Karen L. Mohlke,Richard N. Bergman,Jaakko Tuomilehto,Bernhard O. Boehm,Christian Gieger,Kristian Hveem,Stéphane Cauchi,Philippe Froguel,Philippe Froguel,Damiano Baldassarre,Elena Tremoli,Steve E. Humphries,Danish Saleheen,John Danesh,Erik Ingelsson,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Raimund Erbel,Karl-Heinz Jöckel,Susanne Moebus,Annette Peters,Thomas Illig,Ulf de Faire,Anders Hamsten,Andrew D. Morris,Peter Donnelly,Timothy M. Frayling,Andrew T. Hattersley,Eric Boerwinkle,Eric Boerwinkle,Olle Melander,Sekar Kathiresan,Sekar Kathiresan,Peter M. Nilsson,Panos Deloukas,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Leif Groop,Kari Stefansson,Kari Stefansson,Frank B. Hu,James S. Pankow,Josée Dupuis,Josée Dupuis,James B. Meigs,James B. Meigs,David Altshuler,David Altshuler,Michael Boehnke,Mark I. McCarthy +232 more
TL;DR: This article conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent, and identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association.
Journal ArticleDOI
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TL;DR: It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
OtherDOI
Bile Acid Metabolism and Signaling
TL;DR: Enterohepatic circulation of bile acids from the liver to intestine and back to the liver plays a central role in nutrient absorption and distribution, and metabolic regulation and homeostasis.
References
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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Mitsuhiro Watanabe,Sander M. Houten,Chikage Mataki,Marcelo A. Christoffolete,Brian W. Kim,Hiroyuki Sato,Nadia Messaddeq,John W. Harney,Osamu Ezaki,Tatsuhiko Kodama,Kristina Schoonjans,Antonio C. Bianco,Johan Auwerx +12 more
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Textbook of Biochemistry With Clinical Correlations
TL;DR: Textbook of biochemistry: with clinical correlations, Textbook of bioinformatics: withclinical correlations, and more.
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Fuel Metabolism in Starvation
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