L
Liang Zheng
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 44
Citations - 8226
Liang Zheng is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 25, co-authored 29 publications receiving 6625 citations. Previous affiliations of Liang Zheng include University of Strathclyde & University of Glasgow.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Oliver D. K. Maddocks,Celia R. Berkers,Susan M. Mason,Liang Zheng,Karen Blyth,Eyal Gottlieb,Karen H. Vousden +6 more
TL;DR: It is shown that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle.
Journal ArticleDOI
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Masahiro Morita,Simon-Pierre Gravel,Valérie Chénard,Kristina Sikström,Liang Zheng,Tommy Alain,Valentina Gandin,Daina Avizonis,Meztli Arguello,Chadi Zakaria,Shannon McLaughlan,Yann Nouët,Arnim Pause,Michael Pollak,Eyal Gottlieb,Ola Larsson,Julie St-Pierre,Ivan Topisirovic,Nahum Sonenberg +18 more
TL;DR: It is demonstrated that mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs).
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p53 status determines the role of autophagy in pancreatic tumour development
Mathias T. Rosenfeldt,Jim O'Prey,Jennifer P. Morton,Colin Nixon,Gillian M. Mackay,Agata Mrowinska,Amy Au,Taranjit Singh Rai,Liang Zheng,Rachel A. Ridgway,Peter D. Adams,Kurt I. Anderson,Eyal Gottlieb,Owen J. Sansom,Kevin M. Ryan +14 more
TL;DR: It is shown, in a humanized genetically-modified mouse model of pancreatic ductal adenocarcinoma (PDAC), that autophagy’s role in tumour development is intrinsically connected to the status of the tumour suppressor p53, and treatment with hydroxychloroquine significantly accelerates tumour formation in mice containing oncogenic Kras but lacking p53.
Journal ArticleDOI
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Joanna Kaplon,Liang Zheng,Katrin Meissl,Barbara Chaneton,Vitaly A. Selivanov,Gillian M. Mackay,Sjoerd H. van der Burg,Elizabeth M. E. Verdegaal,Marta Cascante,Tomer Shlomi,Tomer Shlomi,Eyal Gottlieb,Daniel S. Peeper +12 more
TL;DR: It is shown that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAFV600E, an oncogene commonly mutated in melanoma and other cancers, and a mechanistic relationship between OIS and a key metabolic signalling axis is revealed, which may be exploited therapeutically.