Journal ArticleDOI
Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
Amal H. Aly,RuAngelie Edrada-Ebel,Ine Dewi Indriani,Victor Wray,Werner E G Müller,Frank Totzke,Ute Zirrgiebel,Christoph Schächtele,Michael H.G. Kubbutat,Wenhan Lin,Peter Proksch,Rainer Ebel +11 more
TLDR
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp.Abstract:
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibited cytotoxic activity when tested in vitro against L5178Y cells. Chromatographic separation of the extracts yielded 15 natural products, out of which seven were new compounds, with both fungal extracts differing considerably with regard to their secondary metabolites. Compounds 1, 2, 3, 6, and 7 showed cytotoxic activity with EC 50 values ranging from 1.7 to 7.8 microg/mL. When analyzed in vitro for their inhibitory potential against 24 different protein kinases, compounds 1- 3, 5- 8, and 15 inhibited several of these enzymes (IC 50 values 0.22-9.8 microg/mL). Interestingly, compounds 1, 3, and 6 were also identified as constituents of an extract derived from healthy leaves of the host plant P. senegalense, thereby indicating that the production of natural products by the endophyte proceeds also under in situ conditions within the plant host.read more
Citations
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products
TL;DR: This overview will highlight the chemical potential of endophytic fungi with focus on the detection of pharmaceutically valuable plant constituents, e.g. paclitaxel, camptothecin and podophyllotoxin, as products of fungal biosynthesis, and new bioactive metabolites reported in recent years from fungal endophytes of terrestrial and mangrove plants.
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Fungal endophytes: unique plant inhabitants with great promises
TL;DR: The chemical potential of endophytic fungi for drug discovery will be discussed with focus on the detection of pharmaceutically valuable plant constituents as products of fungal biosynthesis.
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Anticancer compounds derived from fungal endophytes: their importance and future challenges.
TL;DR: This is a review of anticancer agents isolated from endophytic fungi from 1990–2010, based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines.
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Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products
TL;DR: This protocol gives a detailed description of methods useful for the isolation and cultivation of fungi associated with various marine organisms for the extraction, characterization and structure elucidation of biologically active secondary metabolites produced by these marine-derived endophytic fungi.
References
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High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoids
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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more
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Bioprospecting for Microbial Endophytes and Their Natural Products
Gary A. Strobel,Bryn Daisy +1 more
TL;DR: Endophytic microorganisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic, which may produce a plethora of substances of potential use to modern medicine, agriculture, and industry.
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Endophytes: a rich source of functional metabolites.
Ren-Xiang Tan,W. X. Zou +1 more
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Fungal Endophytes in Stems and Leaves: From Latent Pathogen to Mutualistic Symbiont
TL;DR: It is surmised that endophytes may be as common among plants as are mycorrhyzae, and inducible mutualists grow rapidly and produce toxins against herbivores when damaged host tissues provide new sites for infection.