F
Frank Totzke
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 80
Citations - 3859
Frank Totzke is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Kinase & Protein kinase A. The author has an hindex of 29, co-authored 76 publications receiving 3613 citations. Previous affiliations of Frank Totzke include University of Düsseldorf & Braunschweig University of Technology.
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Journal Article
PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration
J.M. Wood,G. Bold,Elisabeth Buchdunger,Robert Cozens,Stefano Ferrari,J. Frei,Francesco Hofmann,J. Mestan,Helmut Mett,Terence O'reilly,E Persohn,Johannes Rösel,Christian Schnell,David R. Stover,Andreas Theuer,H Towbin,F Wenger,Kathie Woods-Cook,Andreas Menrad,Gerhard Siemeister,Michael Schirner,Thierauch Kh,Martin R. Schneider,Joachim Drevs,Georg Martiny-Baron,Frank Totzke +25 more
TL;DR: A novel compound with therapeutic potential for the treatment of solid tumors and other diseases where angiogenesis plays an important role, PTK787/ZK 222584 is very well tolerated and does not impair wound healing.
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Roscovitine Targets, Protein Kinases and Pyridoxal Kinase
Stéphane Bach,Marie Knockaert,Jens Reinhardt,Olivier Lozach,Sophie Schmitt,Blandine Baratte,Marcel Koken,Stephen P. Coburn,Lin Tang,Tao Jiang,Dong-Cai Liang,Hervé Galons,Jean-Francois Dierick,Lorenzo A. Pinna,Flavio Meggio,Frank Totzke,Christoph Schächtele,Andrea S. Lerman,Amancio Carnero,Yongqin Wan,Nathanael S. Gray,Laurent Meijer +21 more
TL;DR: The results show that (R)-roscovitine is rather selective for CDKs, in fact most kinases are not affected, but it binds an unexpected, non-protein kinase target, pyridoxal kinase, the enzyme responsible for phosphorylation and activation of vitamin B6.
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Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1
Bernhard Barleon,Frank Totzke,Christel Herzog,Stephen Blanke,Elisabeth Kremmer,Gerhard Siemeister,Dieter Marmé,Georg Martiny-Baron +7 more
TL;DR: The binding of VEGF to sFLT-1(3) could be competed with placenta growth factor (PlGF), a V EGF-related ligand, suggesting that high affinity binding ofVEGF and PlGF is mediated by the same or closely related contact sites on sFLt-1.
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Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
Amal H. Aly,RuAngelie Edrada-Ebel,Ine Dewi Indriani,Victor Wray,Werner E G Müller,Frank Totzke,Ute Zirrgiebel,Christoph Schächtele,Michael H.G. Kubbutat,Wenhan Lin,Peter Proksch,Rainer Ebel +11 more
TL;DR: From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp.
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Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors.
Bernhard Barleon,Petra Reusch,Frank Totzke,Christel Herzog,Christoph Keck,Georg Martiny-Baron,Dieter Marmé +6 more
TL;DR: The presence of an sVEGFR-1 in human serum and plasma of normal male and female donors strongly suggests that it plays an important role as a naturally occurring VEGF antagonist in the regulation and availability of VEGf-mediated biological activities in vivo.