R
Raman K. Bakshi
Researcher at Merck & Co.
Publications - 63
Citations - 1640
Raman K. Bakshi is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Melanocortin. The author has an hindex of 18, co-authored 63 publications receiving 1589 citations.
Papers
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Journal ArticleDOI
Receptor for motilin identified in the human gastrointestinal system.
Scott D. Feighner,Carina P. Tan,Karen K. McKee,Oksana C. Palyha,Donna L. Hreniuk,Sheng-Shung Pong,Christopher P. Austin,David J. Figueroa,Douglas J. MacNeil,Margaret A. Cascieri,Ravi P. Nargund,Raman K. Bakshi,Mark Abramovitz,Rino Stocco,Stacia Kargman,Gary P. O'Neill,Lex H. T. Van Der,Ploeg,Jilly F. Evans,Arthur A. Patchett,Roy G. Smith,Andrew D. Howard +21 more
TL;DR: Development of motilin receptor agonists and antagonists may be useful in the treatment of multiple disorders of GI motility.
Journal ArticleDOI
Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.
Iyassu K. Sebhat,William J. Martin,Zhixiong Ye,Khaled Barakat,Ralph T. Mosley,David B. R. Johnston,Raman K. Bakshi,Palucki Brenda,David H. Weinberg,Tanya MacNeil,Rubana N. Kalyani,Rui Tang,Ralph A. Stearns,Randy R. Miller,Constantin Tamvakopoulos,Alison M. Strack,Erin McGowan,Doreen E. Cashen,Jennifer E. Drisko,Gary J Hom,Andrew D. Howard,D. Euan MacIntyre,Lex H.T. Van der Ploeg,and Arthur A. Patchett,Ravi P. Nargund +24 more
TL;DR: 1, a potent, selective, small-molecule agonist of the MC4 receptor, is reported, which confirms the food intake lowering effects of MC4R agonism and suggests another role for the receptor in the stimulation of erectile activity.
Patent
Melanocortin receptor agonists
TL;DR: In this paper, certain novel compounds and derivatives of the human melanocortin receptor(s) and, in particular, are selective agonists of the MC-4 receptor (MC-4R).
Journal ArticleDOI
Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
Herbert G. Bull,Margarita Garcia-Calvo,Stefan Andersson,Walter F. Baginsky,H. Karen Chan,Dina E. Ellsworth,Randall R. Miller,Ralph A. Stearns,Raman K. Bakshi,Gary H. Rasmusson,Richard L. Tolman,Robert W. Myers,and John W. Kozarich,Georgianna Harris +13 more
TL;DR: The intermediate NADP−dihydrofinasteride adduct can be recovered intact by denaturation of the enzyme−inhibitor complex and has been purified.
Patent
17-ethers and thioethers of 4-aza-steroids.
TL;DR: The 5α-reductase inhibitors are useful for the treatment of hyperandrogenic disease conditions and diseases of the skin and scalp as discussed by the authors, where the compounds of formula (I), wherein Z contains an ether or thioether moiety, are inhibitors of the 5α reductase enzyme and isozymes thereof.