R
Rukshana Shroff
Researcher at Great Ormond Street Hospital
Publications - 236
Citations - 9700
Rukshana Shroff is an academic researcher from Great Ormond Street Hospital. The author has contributed to research in topics: Kidney disease & Dialysis. The author has an hindex of 41, co-authored 196 publications receiving 7369 citations. Previous affiliations of Rukshana Shroff include Norwegian University of Science and Technology & Great Ormond Street Hospital for Children NHS Foundation Trust.
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Journal ArticleDOI
Executive summary of the 2017 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update: what’s changed and why it matters
Markus Ketteler,Geoffrey A. Block,Pieter Evenepoel,Masafumi Fukagawa,Charles A. Herzog,Linda M. McCann,Sharon M. Moe,Sharon M. Moe,Rukshana Shroff,Marcello Tonelli,Nigel D Toussaint,Marc G. Vervloet,Mary B. Leonard +12 more
TL;DR: The KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD represents a selective update of the prior CKDMBD Guideline published in 2009.
Journal ArticleDOI
Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis
Rukshana Shroff,Rosamund McNair,Nichola Figg,Jeremy N. Skepper,Leon J. Schurgers,Ashmeet Gupta,Melanie P. Hiorns,Ann E. Donald,John E. Deanfield,Lesley Rees,Catherine M. Shanahan +10 more
TL;DR: This study shows that Ca accumulation begins predialysis, but it is the induction of VSMC apoptosis in dialysis that is the key event in disabling VSMC defense mechanisms and leading to overt calcification, eventually with clinically detectable vascular damage.
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Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion
Alexander N. Kapustin,Martijn L. Chatrou,Ignat Drozdov,Ying Zheng,Sean M. Davidson,Daniel Soong,Malgorzata Furmanik,Pilar Sanchis,Rafael Torres Martin de Rosales,D Alvarez-Hernandez,Rukshana Shroff,Xiaoke Yin,Karin H. Müller,Jeremy N. Skepper,Manuel Mayr,Chris P. M. Reutelingsperger,Adrian H. Chester,Sergio Bertazzo,Leon J. Schurgers,Catherine M. Shanahan +19 more
TL;DR: MVs are identified as exosomes and it is shown that factors that can increase exosome release can promote vascular calcification in response to environmental calcium stress and Modulation of the exOSome release pathway may be as a novel therapeutic target for prevention.
Journal ArticleDOI
Mechanistic Insights into Vascular Calcification in CKD
TL;DR: Current understanding of the process of vascular calcification is discussed, focusing specifically on the discrete and synergistic effects of calcium and phosphate in mediating vascular smooth muscle cell apoptosis, osteochondrocytic differentiation, vesicle release, calcification inhibitor expression, senescence, and death.
Journal ArticleDOI
Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging
Cassandra D. Ragnauth,Derek T. Warren,Yiwen Liu,Rosamund McNair,Tamara Tajsic,Nichola Figg,Rukshana Shroff,Jeremy N. Skepper,Catherine M. Shanahan +8 more
TL;DR: It is shown that prelamin A is a novel biomarker of VSMC aging and disease that acts to accelerate senescence and represents a novel target to ameliorate the effects of age-induced vascular dysfunction.