R
Ruochen Zang
Researcher at Washington University in St. Louis
Publications - 11
Citations - 1169
Ruochen Zang is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Virus & Coronavirus. The author has an hindex of 6, co-authored 8 publications receiving 671 citations. Previous affiliations of Ruochen Zang include Ocean University of China.
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Journal ArticleDOI
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
Ruochen Zang,Ruochen Zang,Maria Florencia Gomez Castro,Broc T. McCune,Qiru Zeng,Paul W. Rothlauf,Paul W. Rothlauf,Naomi M. Sonnek,Zhuoming Liu,Kevin Brulois,Kevin Brulois,Xin Wang,Harry B. Greenberg,Harry B. Greenberg,Michael S. Diamond,Matthew A. Ciorba,Sean P. J. Whelan,Siyuan Ding +17 more
TL;DR: In this article, the authors reported productive infection of SARS-CoV-2 in ACE2+ mature enterocytes in human small intestinal enteroids, which may contribute to local and systemic illness and overall disease progression.
Journal ArticleDOI
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
Ruochen Zang,Ruochen Zang,James Brett Case,Eylan Yutuc,Xiucui Ma,Xiucui Ma,Sheng Shen,Maria Florencia Gomez Castro,Zhuoming Liu,Qiru Zeng,Haiyan Zhao,Juhee Son,Paul W. Rothlauf,Paul W. Rothlauf,Alex J. B. Kreutzberger,Gaopeng Hou,Hu Zhang,Sayantan Bose,Xin Wang,Michael D. Vahey,Kartik Mani,Kartik Mani,William J. Griffiths,Tom Kirchhausen,Daved H. Fremont,Haitao Guo,Abhinav Diwan,Abhinav Diwan,Yuqin Wang,Michael S. Diamond,Sean P. J. Whelan,Siyuan Ding +31 more
TL;DR: The approach is to harness the germline-encoded interferon antiviral response to inhibit SARS-CoV-2 replication thereby limiting its pathogenicity and providing the molecular basis for its therapeutic development.
Journal ArticleDOI
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.
Qiao Lu,Jia Liu,Shuai Zhao,Maria Florencia Gomez Castro,Maudry Laurent-Rolle,Jianbo Dong,Xiaojuan Ran,Payal Damani-Yokota,Hongzhen Tang,Triantafyllia R. Karakousi,Juhee Son,Maria E. Kaczmarek,Ze Zhang,Stephen T. Yeung,Broc T. McCune,Rita E. Chen,Fei Tang,Xianwen Ren,Xufeng Chen,Jack C.-C. Hsu,Marianna Teplova,Betty Huang,Haijing Deng,Zhilin Long,Tenny Mudianto,Shumin Jin,Peng Lin,Jasper Du,Ruochen Zang,Tina Tianjiao Su,Alberto Herrera,Ming Zhou,Renhong Yan,Jia Cui,James Zhu,Qiang Zhou,Tao Wang,Jianzhu Ma,Sergei B. Koralov,Zemin Zhang,Iannis Aifantis,Leopoldo N. Segal,Michael S. Diamond,Kamal M. Khanna,Kenneth A. Stapleford,Peter Cresswell,Yue Liu,Siyuan Ding,Qi Xie,Jun Wang +49 more
TL;DR: In this paper, using a myeloid cell receptor-focused ectopic expression screen, the authors identified several C-type lectins (DC-SIGN, L-Sign, LSECtin, ASGR1, and CLEC10A) and Tweety family member 2 (TTYH2) as glycan-dependent binding partners of the SARS-CoV-2 spike.
Posted ContentDOI
TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes
Ruochen Zang,Ruochen Zang,Maria Florencia Gomez Castro,Broc T. McCune,Qiru Zeng,Paul W. Rothlauf,Naomi M. Sonnek,Zhuoming Liu,Kevin Brulois,Kevin Brulois,Xin Wang,Harry B. Greenberg,Harry B. Greenberg,Michael S. Diamond,Matthew A. Ciorba,Sean P. J. Whelan,Siyuan Ding +16 more
TL;DR: The results highlight the intestine as a potential site of SARS-CoV-2 replication, which may contribute to local and systemic illness and overall disease progression.
Posted ContentDOI
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Siyuan Ding,Ruochen Zang,James Brett Case,Maria Florencia Gomez Castro,Zhuoming Liu,Qiru Zeng,Haiyan Zhao,Juhee Son,Paul W. Rothlauf,Gaopeng Hou,Sayantan Bose,Xin Wang,Michael D. Vahey,Tom Kirchhausen,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +16 more
TL;DR: Mechanistically, internalized 25HC accumulates in the late endosomes and blocks cholesterol export, thereby restricting SARS-CoV-2 spike protein catalyzed membrane fusion and providing the molecular basis for its possible therapeutic development.