M
Mark R. Wade
Researcher at Eli Lilly and Company
Publications - 26
Citations - 2888
Mark R. Wade is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Acetylcholine & Receptor. The author has an hindex of 19, co-authored 25 publications receiving 2590 citations. Previous affiliations of Mark R. Wade include Amgen.
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Journal ArticleDOI
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
William L. Holland,Russell A. Miller,Zhao V. Wang,Kai Sun,Brian M. Barth,Hai H. Bui,Kathryn Davis,Benjamin T. Bikman,Nils Halberg,Nils Halberg,Joseph M. Rutkowski,Mark R. Wade,Vincent M. Tenorio,Ming Shang Kuo,Joseph T. Brozinick,Bei B. Zhang,Morris J. Birnbaum,Scott A. Summers,Scott A. Summers,Scott A. Summers,Philipp E. Scherer +20 more
TL;DR: Observations suggest a unifying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolipid metabolism as its core upstream signaling component.
Journal ArticleDOI
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
William L. Holland,Andrew C. Adams,Joseph T. Brozinick,Hai H. Bui,Yukiko Miyauchi,Christine M. Kusminski,Steven M. Bauer,Mark R. Wade,Esha Singhal,Christine C. Cheng,Katherine Volk,Ming Shang Kuo,Ruth Gordillo,Alexei Kharitonenkov,Philipp E. Scherer +14 more
TL;DR: It is shown that FGF21 rapidly and robustly stimulates adiponectin secretion in rodents while diminishing accumulation of ceramides in obese animals, and that F GF21 critically depends on adip onectin to exert its glycemic and insulin sensitizing effects.
Journal ArticleDOI
The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone
Christelle Gras,Bénédicte Amilhon,Bénédicte Amilhon,Eve M. Lepicard,Eve M. Lepicard,Odile Poirel,Odile Poirel,Jacqueline Vinatier,Jacqueline Vinatier,Marc Herbin,Sylvie Dumas,Eleni T. Tzavara,Eleni T. Tzavara,Mark R. Wade,George G. Nomikos,Naïma Hanoun,Françoise Saurini,M.L. Kemel,Bruno Gasnier,Bruno Giros,Bruno Giros,Bruno Giros,Salah El Mestikawy,Salah El Mestikawy,Salah El Mestikawy +24 more
TL;DR: It is proposed that this vesicular synergy between two transmitters is the result of the unbalanced bioenergetics of VAChT, which requires anion co-entry for continuing vesicle filling.
Journal ArticleDOI
M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies.
Eleni T. Tzavara,Frank P. Bymaster,Richard J. Davis,Mark R. Wade,Kenneth W. Perry,Jürgen Wess,David L. McKinzie,C C Felder,George G. Nomikos +8 more
TL;DR: This study showed that dopaminergic neurotransmission is highly dependent on M4 cholinergic muscarinic receptor function, and proposed that M4 receptor agonists could represent an innovative strategy for the treatment of pathologies associated with hyperdopaminergia.
Journal ArticleDOI
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization
Michael D. Lubeck,Robert J. Natuk,Maria Myagkikh,Narender K. Kalyan,Kristine Aldrich,Faruk Sinangil,Shabnam Alipanah,Shri C.S. Murthy,Pranab K. Chanda,Stephen M. Nigida,Phillip D. Markham,Susan Zolla-Pazner,Kathy Steimer,Mark R. Wade,Marvin S. Reitz,Marvin S. Reitz,Larry O. Arthur,Satoshi Mizutani,Alan R. Davis,Paul P. Hung,Robert C. Gallo,Robert C. Gallo,Jorg Eichberg,Marjorie Robert-Guroff +23 more
TL;DR: The results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans.