An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
Clair Crewe,Nolwenn Joffin,Joseph M. Rutkowski,Min Kim,Fang Zhang,Dwight A. Towler,Ruth Gordillo,Philipp E. Scherer +7 more
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TLDR
It is shown that neighboring endothelial cells (ECs) transfer cav1-containing EVs to adipocytes in vivo, which reciprocate by releasing EVs to ECs, which facilitates transfer of plasma constituents from ECs to the adipocyte.About:
This article is published in Cell.The article was published on 2018-10-18 and is currently open access. It has received 238 citations till now. The article focuses on the topics: Extracellular vesicle & Cell signaling.read more
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Adipogenesis and metabolic health
TL;DR: Interestingly, adipose tissue expansion through the generation of new adipocytes (adipogenesis), rather than through increasing adipocyte size, can prevent this metabolic decline, and a better understanding of adipogenesis can inform new strategies to increase metabolic health in humans.
Journal ArticleDOI
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease
TL;DR: The findings that led to these conclusions are reviewed and how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease.
Journal ArticleDOI
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Stephen E. Flaherty,Ambar Grijalva,Xiaoyuan Xu,Eleanore V. Ables,Alireza Nomani,Anthony W. Ferrante +5 more
TL;DR: AdExos are both an alternative pathway of local lipid release and a mechanism by which parenchymal cells can modulate tissue macrophage differentiation and function.
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Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation.
TL;DR: Exosomal miR-21-3p from nicotine-treated macrophages may accelerate the development of atherosclerosis by increasing VSMC migration and proliferation through its target PTEN.
Journal ArticleDOI
Extracellular vesicles in the tumor microenvironment: old stories, but new tales.
TL;DR: In this paper, the authors present updates on major topics that document how extracellular vesicles are implicated in proliferative expansion of cancer cells, promotion of drug resistance, reprogramming of metabolic activity, enhancement of metastatic potential, induction of angiogenesis, and escape from immune surveillance.
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