Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TLDR
A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.About:
This article is published in The Lancet.The article was published on 2002-11-30. It has received 1669 citations till now. The article focuses on the topics: Sputum & Asthma.read more
Citations
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Journal ArticleDOI
Global strategy for asthma management and prevention: GINA executive summary.
Eric D. Bateman,Suzanne S. Hurd,Peter J. Barnes,Jean Bousquet,Jeffrey M. Drazen,JM FitzGerald,Peter G. Gibson,K. Ohta,Paul M. O'Byrne,Søren Pedersen,Emilio Pizzichini,Sean D. Sullivan,Sally E. Wenzel,Heather J. Zar +13 more
TL;DR: It is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained, and the Global Initiative for Asthma recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions.
Journal ArticleDOI
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more
TL;DR: Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided.
Journal ArticleDOI
An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications.
Raed A. Dweik,Peter B. Boggs,Serpil C. Erzurum,Charles G. Irvin,Margaret W. Leigh,Jon O. Lundberg,Anna-Carin Olin,Alan L. Plummer,D. Robin Taylor +8 more
TL;DR: Recommendations to develop evidence-based guidelines for the interpretation of Fe(NO) measurements that incorporate evidence that has accumulated over the past decade are provided.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
References
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Journal ArticleDOI
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
Margaret J Leckie,Anneke ten Brinke,Jamey Khan,Zuzana Diamant,Brian J. O'Connor,Christine M Walls,A. Mathur,Hugh C Cowley,K. Fan Chung,Ratko Djukanovic,Trevor T. Hansel,Stephen T. Holgate,Peter J. Sterk,Peter J. Barnes +13 more
TL;DR: A single dose of monoclonal antibody to IL-5 decreased blood eosinophils for up to 16 weeks and sputum eosInophils at 4 weeks, which has considerable therapeutic potential for asthma and allergy, however, the findings question the role of eos inophils in mediating the late asthmatic response and causing airway hyper-responsiveness.
Journal ArticleDOI
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
Journal ArticleDOI
Mast-Cell Infiltration of Airway Smooth Muscle in Asthma
Christopher E. Brightling,Peter Bradding,F A Symon,Stephen T. Holgate,Andrew J. Wardlaw,Ian D. Pavord +5 more
TL;DR: The infiltration of airway smooth muscle by mast cells is associated with the disordered airway function found in asthma.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group.
Jacob K. Sont,Luuk N.A. Willems,E.H.D. Bel,J. H. J. M. Van Krieken,Jan P. Vandenbroucke,P. J. Sterk +5 more
TL;DR: It is concluded that reducing AHR in conjunction with optimizing symptoms and lung function leads to more effective control of asthma while alleviating chronic airways inflammation, implying a role for the monitoring of AHR or other surrogate markers of inflammation in the long-term management of asthma.