Ryan Brewster

TL;DR: This work identifies PI3K signaling as an important target for precision medicine trials in meningioma patients using high-resolution array-comparative genomic hybridization to prospectively characterize copy-number changes.

TL;DR: It is shown that familial and sporadic BAP1-mutated rhabdoid meningiomas are clinically aggressive, requiring intensive clinical management, and implicate ubiquitin deregulation in the pathogenesis of these high-grade malignancies.

TL;DR: The recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas, and these insights may serve to craft a molecular taxonomy for meniomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.

TL;DR: The goal is to provide guidelines for both patients and physicians, as well as a valuable patient handout in preparation for their visit, and to provide a steep learning curve as they have learned.

TL;DR: The authors review the etiology, pathophysiology, presentation, diagnosis, surgical options, and outcomes in the treatment of superior semicircular canal dehiscence syndrome, with a focus on potential pitfalls that may be encountered during clinical management.