Intraoperative molecular imaging can identify lung adenocarcinomas during pulmonary resection
Olugbenga T. Okusanya,Elizabeth DeJesus,Jack Jiang,Ryan Judy,Ollin Venegas,Charuhas Deshpande,Daniel F. Heitjan,Shuming Nie,Philip S. Low,Sunil Singhal +9 more
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TLDR
Intraoperative molecular imaging with a targeted contrast agent can identify lung adenocarcinomas, and this technology is currently useful in patients with subpleural tumors, irrespective of size.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2015-07-01 and is currently open access. It has received 80 citations till now. The article focuses on the topics: Adenocarcinoma & Lung cancer.read more
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Latest developments in molecular tracers for fluorescence image-guided cancer surgery
TL;DR: Preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery are discussed.
Journal ArticleDOI
Fluorescence-Guided Surgery.
TL;DR: Current and new fluorescent probes that may assist Fluorescence-guided surgery (FGS) are described, which may allow more complete resections and improve safety by avoiding unnecessary damage to normal tissue.
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Oncologic Procedures Amenable to Fluorescence-guided Surgery
Kiranya E. Tipirneni,Jason M. Warram,Lindsay S. Moore,Andrew C. Prince,Esther de Boer,Aditi Jani,Irene Wapnir,Joseph C. Liao,Joseph C. Liao,Michael Bouvet,Nicole K. Behnke,Mary T. Hawn,George A. Poultsides,Alexander L. Vahrmeijer,William R. Carroll,Kurt R. Zinn,Eben L. Rosenthal +16 more
TL;DR: The use of FGS as a surgical guide enhancement has the potential to improve survival and quality of life outcomes for patients as the number of clinical trials rise each year.
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Tumor-targeted Dual-modality Imaging to Improve Intraoperative Visualization of Clear Cell Renal Cell Carcinoma: A First in Man Study.
Marlène C.H. Hekman,Mark Rijpkema,Constantijn H.J. Muselaers,Egbert Oosterwijk,C.A. Hulsbergen-van de Kaa,Otto C. Boerman,Wim J.G. Oyen,Johannes F. Langenhuijsen,Peter F.A. Mulders +8 more
TL;DR: This first in man study shows that tumor-targeted dual-modality imaging using 111In-DOTA-girentuximab-IRDye800CW is safe and can be used for intraoperative guidance of ccRCC resection.
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Real-time fluorescence imaging in intraoperative decision making for cancer surgery.
Lorraine J. Lauwerends,Pieter B A A van Driel,Robert J. Baatenburg de Jong,Jose A. Hardillo,Senada Koljenović,Gerwin J. Puppels,Laura Mezzanotte,Clemens W.G.M. Löwik,Eben L. Rosenthal,Alexander L. Vahrmeijer,Stijn Keereweer +10 more
TL;DR: In this paper, the authors explore the study designs of existing trials of fluorescence-guided surgery that allow us to extract information on potential changes in intraoperative decision making, such as additional or more conservative resections.
References
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Cancer statistics, 2013
TL;DR: Overall cancer death rates have declined 20% from their peak in 1991 to 2009 and can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket and other underserved populations.
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Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
Gooitzen M. van Dam,George Themelis,Lucia M. A. Crane,Niels J. Harlaar,Niels J. Harlaar,Rick G. Pleijhuis,W. Kelder,Athanasios Sarantopoulos,Johannes S. de Jong,Henriette J. G. Arts,Ate G.J. van der Zee,Joost Bart,Philip S. Low,Vasilis Ntziachristos +13 more
TL;DR: In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α–targeted fluorescent agent showcased the potential applications in patients with Ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
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Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
Nikki Parker,Mary Jo Turk,Elaine Westrick,Jeffrey D. Lewis,Philip S. Low,Philip S. Low,Christopher P. Leamon +6 more
TL;DR: Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics.
Journal Article
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.
Steven D. Weitman,Richard H. Lark,Leslie R. Coney,Daniel W. Fort,Verna Frasca,Vincent R. Zurawski,Barton A. Kamen +6 more
TL;DR: The limited normal tissue distribution of the folate receptor is revealed, a cell surface protein which may be a useful immunological or pharmacological target for the development of selective cancer therapy.
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Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines: Physiologic and clinical implications
TL;DR: Little is known about the tissue specificities of FR β and FR‐α, but there is no report on the relative expression of FR‐β in any tissue other than in placenta.