S
S.A. Hoare
Researcher at Lincoln's Inn
Publications - 10
Citations - 975
S.A. Hoare is an academic researcher from Lincoln's Inn. The author has contributed to research in topics: Breast cancer & Receptor. The author has an hindex of 8, co-authored 10 publications receiving 963 citations.
Papers
More filters
Journal ArticleDOI
Estrogen receptors alpha and beta form heterodimers on DNA.
TL;DR: It is shown that ERα and ERβ, expressed both in vitro and in vivo, form heterodimers which bind to DNA with an affinity similar to that of ER α and greater than that ofERβ homodimer.
Journal ArticleDOI
Differential interaction of steroid hormone receptors with LXXLL motifs in SRC-1a depends on residues flanking the motif.
Maurice Needham,Stephanie Raines,Jane McPheat,Clare Stacey,Jonathan Ellston,S.A. Hoare,Malcolm G. Parker +6 more
TL;DR: It is shown that the interactions of steroid receptor co-activator-1 interacts with the ligand binding domains of a number of different receptors by means of LXXLL motifs depend not only on the L XXLL motif itself but also on residues flanking the motif.
Journal ArticleDOI
Binding of oestradiol to blood proteins and aetiology of breast cancer
J.W. Moore,G.M.G. Clark,S.A. Hoare,Rosemary R. Millis,John L. Hayward,M. K. Quinlan,D.Y. Wang,R.D. Bulbrook +7 more
TL;DR: A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non‐protein‐bound and albumin‐bound fractions (the bio‐available fraction) and a lower proportion in the sex‐hormone‐bound fraction.
Journal ArticleDOI
Identification of phosphorylation sites in the mouse oestrogen receptor
TL;DR: A region of AF-1 that encompasses Ser-122 appears to interact with AF-2 in the full-length receptor, and a reduction of transcriptional activity was observed when Ser- 122 was mutated in the context of mutations in a putative amphipathic alpha-helix involved in AF- 2 activity.
Journal ArticleDOI
Plasma and urinary androgens in women with varying degrees of risk of breast cancer.
TL;DR: The significant correlation between plasma androgen levels and the amount of urinary aetiocholanolone measured 5 yr previously indicates that abnormalities in androgen production are not transient.