S
S du Manoir
Researcher at National Institutes of Health
Publications - 14
Citations - 3697
S du Manoir is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Comparative genomic hybridization & Cytogenetics. The author has an hindex of 12, co-authored 14 publications receiving 3654 citations. Previous affiliations of S du Manoir include Maastricht University.
Papers
More filters
Journal ArticleDOI
Multicolor Spectral Karyotyping of Human Chromosomes
Evelin Schröck,S du Manoir,T Veldman,B Schoell,Johannes Wienberg,Malcolm A. Ferguson-Smith,Yi Ning,David H. Ledbetter,Irit Bar-Am,D. Soenksen,Yuval Garini,Thomas Ried +11 more
TL;DR: Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization, and all human chromosomes were simultaneously identified.
Journal ArticleDOI
Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix
K. Heselmeyer,Evelin Schröck,S du Manoir,Harald Blegen,Keerti V. Shah,Rüdiger Steinbeck,Gert Auer,Thomas Ried +7 more
TL;DR: It is concluded that the gain of chromosome 3q that occurs in HPV16-infected, aneuploid cells represents a pivotal genetic aberration at the transition from severe dysplasia/CIS to invasive cervical carcinoma.
Journal ArticleDOI
Multicolour spectral karyotyping of mouse chromosomes.
Marek Liyanage,Allen E. Coleman,S du Manoir,T Veldman,S McCormack,Robert B. Dickson,Carrolee Barlow,Anthony Wynshaw-Boris,Siegfried Janz,Johannes Wienberg,Malcolm A. Ferguson-Smith,Evelin Schröck,Thomas Ried +12 more
TL;DR: Spectral karyotyping (SKY) is applied to chemically induced plasmocytomas, mammary gland tumours from transgenic mice overexpressing the c-myc onco-gene and thymomas from mice deficient for the ataxia telangiectasia (Atm) gene to demonstrate the potential of SKY to identify complex chromosomal aberrations in mouse models of human carcinogenesis.
Journal Article
Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.
Michael R. Speicher,B Schoell,S du Manoir,Evelin Schröck,Thomas Ried,Thomas Cremer,S Störkel,A Kovacs,Gyula Kovacs +8 more
TL;DR: A specific combination of multiple chromosomal losses characterizes chromophobe renal cell carcinomas and may help to differentiate them unequivocally from other types of kidney cancer.
Journal Article
Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization.
Thomas Ried,Iver Petersen,H Holtgreve-Grez,Michael R. Speicher,Evelin Schröck,S du Manoir,Thomas Cremer +6 more
TL;DR: Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens, finding the most abundant genetic changes include DNA losses of chromosome arms 3p, 5q, 10q, 13q, and 17p and DNA gains of 3q, 5p, 8q and 17q.