Yi Ning

TL;DR: Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization, and all human chromosomes were simultaneously identified.

TL;DR: Three cDNAs, referred to as senescent cell-derived inhibitors (sdi), that exhibit DNA synthesis-inhibitory activity when introduced into young cycling cells, were successfully identified and expression of one of them, sdi1, increased 10- to 20-fold in senescent compared with young cells and the increase in RNA closely paralleled the onset of the senescent phenotype and loss of cell proliferation.

TL;DR: It is suggested that extra dose of SOX9 is sufficient to initiate testis differentiation in the absence of SRY, and other SRY-negative XX sex-reversed individuals deserve thorough investigation of SoX9 gene.

TL;DR: Pretreatment cytogenetics adds to other prognostic factors in older AML patients, and patients with complex > or = 5 appear to benefit minimally from current treatment and are better suited for investigational therapy or supportive care.

TL;DR: In isolation and characterization of a complete set of specific FISH probes representing each human telomere, this provides a 10-fold improvement in deletion detection sensitivity compared with high-resolution cytogenetics.