S. Heron

TL;DR: The results suggest NGS can provide complete, unambiguous, high-resolution HLA typing and can be a useful tool for complete genomic characterization of new HLA alleles and for completion of sequence for existing, partially sequenced alleles.

TL;DR: The results demonstrate the feasibility and significant benefit of HLA typing by NGS as this technology is highly accurate, eliminates virtually all ambiguities, provides complete sequencing information for the length of the HLA gene and forms the basis for utilizing a single methodology for HLA Typing in the immunogenetics labs.

TL;DR: The role of high‐resolution 2‐field HLA typing (HR‐2F) in SOT is assessed by retrospectively evaluating NGS‐typed pre‐ and post‐SOT cases, whereby 21% of the cases required HR‐ 2F typing by Sanger sequencing, as supported by other legacy methods, to properly address posttransplant anti‐HLA antibody issues.

TL;DR: The ST was associated with a higher likelihood of remaining listed and a longer waitlist time without substantially impacting the HT rate, waitlist mortality, or early post-HT outcomes.

TL;DR: The new HLA-DQB1 allele most closely resembles DQB1*02:01:01, differing at a single position 141 (exon 2, codon 15.3).