E
Edward C. Frackelton
Researcher at Children's Hospital of Philadelphia
Publications - 49
Citations - 9721
Edward C. Frackelton is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 39, co-authored 49 publications receiving 9166 citations. Previous affiliations of Edward C. Frackelton include University of Pennsylvania.
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Journal ArticleDOI
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Joseph T. Glessner,Kai Wang,Guiqing Cai,Olena Korvatska,Cecilia E. Kim,Shawn Wood,Haitao Zhang,Annette Estes,Camille W. Brune,Jonathan P. Bradfield,Marcin Imielinski,Edward C. Frackelton,Jennifer Reichert,Emily L. Crawford,Jeffrey Munson,Patrick M. A. Sleiman,Rosetta M. Chiavacci,Kiran Annaiah,Kelly A. Thomas,Cuiping Hou,Wendy Glaberson,James H. Flory,Frederick G. Otieno,Maria Garris,Latha Soorya,Lambertus Klei,Joseph Piven,Kacie J. Meyer,Evdokia Anagnostou,Takeshi Sakurai,Rachel M. Game,Danielle S. Rudd,Danielle Zurawiecki,Christopher J. McDougle,Lea K. Davis,Judith Miller,David J. Posey,Shana M. Michaels,Alexander Kolevzon,Jeremy M. Silverman,Raphael Bernier,Susan E. Levy,Robert T. Schultz,Geraldine Dawson,Thomas Owley,William M. McMahon,Thomas H. Wassink,John A. Sweeney,John I. Nurnberger,Hilary Coon,James S. Sutcliffe,Nancy J. Minshew,Struan F.A. Grant,Maja Bucan,Edwin H. Cook,Joseph D. Buxbaum,Bernie Devlin,Gerard D. Schellenberg,Hakon Hakonarson +58 more
TL;DR: Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
Journal ArticleDOI
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Kai Wang,Haitao Zhang,Deqiong Ma,Maja Bucan,Joseph T. Glessner,Brett S. Abrahams,Daria Salyakina,Marcin Imielinski,Jonathan P. Bradfield,Patrick M. A. Sleiman,Cecilia E. Kim,Cuiping Hou,Edward C. Frackelton,Rosetta M. Chiavacci,Nagahide Takahashi,Takeshi Sakurai,Eric F. Rappaport,Clara Lajonchere,Jeffrey Munson,Annette Estes,Olena Korvatska,Joseph Piven,Lisa I. Sonnenblick,Ana I. Alvarez Retuerto,Edward I. Herman,Hongmei Dong,Ted Hutman,Marian Sigman,Sally J Ozonoff,Ami Klin,Thomas Owley,John A. Sweeney,Camille W. Brune,Rita M. Cantor,Raphael Bernier,John R. Gilbert,Michael L. Cuccaro,William M. McMahon,Judith Miller,Matthew W. State,Thomas H. Wassink,Hilary Coon,Susan E. Levy,Robert T. Schultz,John I. Nurnberger,Jonathan L. Haines,James S. Sutcliffe,Edwin H. Cook,Nancy J. Minshew,Joseph D. Buxbaum,Geraldine Dawson,Struan F.A. Grant,Daniel H. Geschwind,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Hakon Hakonarson +55 more
TL;DR: The results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to the authors' knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.
Journal ArticleDOI
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Marcin Imielinski,Robert N. Baldassano,Anne M. Griffiths,Richard K Russell,Vito Annese,Marla Dubinsky,Subra Kugathasan,Jonathan P. Bradfield,Thomas D. Walters,Patrick M. A. Sleiman,Cecilia E. Kim,Aleixo M. Muise,Kai Wang,Joseph T. Glessner,Shehzad Ahmed Saeed,Haitao Zhang,Edward C. Frackelton,Cuiping Hou,James H. Flory,George Otieno,Rosetta M. Chiavacci,Robert W. Grundmeier,Massimo Castro,Anna Latiano,Bruno Dallapiccola,Joanne M. Stempak,Debra J. Abrams,Kent D. Taylor,Dermot P.B. McGovern,Melvin B. Heyman,George D. Ferry,Barbara S. Kirschner,Jessica T. Lee,Jonah Essers,Richard J. Grand,Michael C. Stephens,Arie Levine,David A. Piccoli,Johan Van Limbergen,Salvatore Cucchiara,Dimitri S. Monos,Stephen L. Guthery,Lee A. Denson,David C. Wilson,Struan F.A. Grant,Mark J. Daly,Mark S. Silverberg,Jack Satsangi,Hakon Hakonarson +48 more
TL;DR: The results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America are reported, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD.
Journal ArticleDOI
Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes
Josephine Elia,Xiaowu Gai,Hongbo Xie,Juan C. Perin,Elizabeth A. Geiger,Joseph T. Glessner,Monica D’Arcy,R. Deberardinis,Edward C. Frackelton,Cecilia Kim,Francesca Lantieri,B. M. Muganga,Li-San Wang,Toshinobu Takeda,Eric F. Rappaport,Struan F.A. Grant,Struan F.A. Grant,Wade H. Berrettini,Marcella Devoto,Tamim H. Shaikh,Tamim H. Shaikh,Hakon Hakonarson,Hakon Hakonarson,Peter White,Peter White +24 more
TL;DR: It is suggested that rare inherited structural variations play an important role in ADHD development and a set of putative candidate genes for further study in the etiology of ADHD are indicated.
Journal ArticleDOI
Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies
Brendan J. Keating,Sam Tischfield,Sam Tischfield,Sarah S. Murray,Tushar Bhangale,Thomas S. Price,Joseph T. Glessner,Luana Galver,Jeffrey C. Barrett,Struan F.A. Grant,Deborah N. Farlow,Hareesh R. Chandrupatla,Mark Hansen,Saad Ajmal,George J. Papanicolaou,Yiran Guo,Mingyao Li,Stephanie DerOhannessian,Paul I.W. de Bakker,Paul I.W. de Bakker,Swneke D. Bailey,Alexandre Montpetit,Andrew C. Edmondson,Kent D. Taylor,Xiaowu Gai,Susanna S. Wang,Myriam Fornage,Tamim H. Shaikh,Leif Groop,Michael Boehnke,Alistair S. Hall,Andrew T. Hattersley,Edward C. Frackelton,Nick Patterson,Charleston W. K. Chiang,Charleston W. K. Chiang,Cecelia E. Kim,Richard R. Fabsitz,Willem H. Ouwehand,Alkes L. Price,Patricia B. Munroe,Mark J. Caulfield,Thomas A. Drake,Eric Boerwinkle,David Reich,David Reich,A. Stephen Whitehead,Thomas P. Cappola,Nilesh J. Samani,A. Jake Lusis,Eric E. Schadt,James G. Wilson,Wolfgang Koenig,Mark I. McCarthy,Sekar Kathiresan,Sekar Kathiresan,Stacey Gabriel,Hakon Hakonarson,Sonia S. Anand,Muredach P. Reilly,James C. Engert,Deborah A. Nickerson,Daniel J. Rader,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Garret A. FitzGerald +66 more
TL;DR: A gene-centric 50 K single nucleotide polymorphism (SNP) array to assess potentially relevant loci across a range of cardiovascular, metabolic and inflammatory syndromes and it is demonstrated that the IBC array can be used to complement GWAS, increasing coverage in high priority CVD-related lociAcross all major HapMap populations.