S. Inui

TL;DR: A cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R) is isolated and shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc ePSilon R in endocytosis.

TL;DR: Results indicate that in spite of the growth inhibitory effect of anti‐CD40, the augmentative effect of PMA is conserved in CD40+ transfectants and suggest that the transfectant might be useful for the study of signal transduction mechanism through CD40.

TL;DR: Results showed that IL 2 could directly act on B cells and provide a differentiation signal through IL 2 receptors distinct from BCDF receptors and Physiologic relevance of IL 2 in the antibody response was discussed.

TL;DR: Activation process of B lymphocytes into immunoglobulin (Ig)-secreting cells can be dissected into three steps, i.e., activation, proliferation and differentiation, and a recent study showed an increased expression of Ia antigen on resting B cells by stimulation with BCGF-I, suggesting the presence of BC GF-I receptors even on rested B cells.

TL;DR: B lymphocytes originate from pluripotent hematopoietic stem cells and differentiate into antibody producing cells through several distinct differentiation stages, which commitment of the antigen specificity in each B cell clone occurs at the stage of pre B cells by two step DNA rearrangements.