M
Masaki Suemura
Researcher at Osaka University
Publications - 68
Citations - 3982
Masaki Suemura is an academic researcher from Osaka University. The author has contributed to research in topics: Immunoglobulin E & CD23. The author has an hindex of 33, co-authored 68 publications receiving 3891 citations.
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Journal ArticleDOI
Interleukin 6 Plays a Key Role in the Development of Antigen-Induced Arthritis
Shiro Ohshima,Yukihiko Saeki,Toru Mima,Mitsuko Sasai,Katsuhiro Nishioka,Shintaro Nomura,Manfred Kopf,Yoshinori Katada,Toshio Tanaka,Masaki Suemura,Tadamitsu Kishimoto +10 more
TL;DR: The authors investigated the role of interleukin (IL) 6 in the development of rheumatoid arthritis and found that IL-6 may play a crucial role in cartilage destruction.
Journal ArticleDOI
Molecular structure of human lymphocyte receptor for immunoglobulin E
Hitoshi Kikutani,S. Inui,Ryoichi Sato,Barsumian Edward L,Hajime Owaki,Katsuhiko Yamasaki,Tsuneyasu Kaisho,Naoto Uchibayashi,Richard R. Hardy,Toshio Hirano,Susumu Tsunasawa,Fumio Sakiyama,Masaki Suemura,Tadamitsu Kishimoto +13 more
TL;DR: A cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R) is isolated and shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc ePSilon R in endocytosis.
Journal ArticleDOI
Two species of human Fcε receptor II (FcεRIICD23): Tissue-specific and IL-4-specific regulation of gene expression
Akira Yokota,Hitoshi Kikutani,Tetsuji Tanaka,Ryoichi Sato,Barsumian Edward L,Masaki Suemura,Tadamitsu Kishimoto +6 more
TL;DR: Sequence analysis of the cloned cDNAs revealed that these Fc epsilon RII species appear to be generated utilizing different transcriptional initiation sites and alternative RNA splicing, which may explain the difference in Fc wtihin B cells and the effector phase of IgE-mediated immunity.
Journal Article
Toxicity pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study
Norihiro Nishimoto,Kazuyuki Yoshizaki,Keiji Maeda,Taro Kuritani,Hitoshi Deguchi,Bunzo Sato,Nobuyuki Imai,Masaki Suemura,Takahiro Kakehi,Nobuhiro Takagi,Tadamitsu Kishimoto +10 more
TL;DR: Repetitive treatment with MRA was safe and normalized acute phase response in patients with RA and optimal dosing schedule was not defined in this small study, but maintenance of serum MRA concentration seemed important to achieve efficacy.
Journal ArticleDOI
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching.
Hitoshi Kikutani,Masaki Suemura,Hajime Owaki,Hiroshige Nakamura,Ryoichi Sato,Katsuhiko Yamasaki,Barsumian Edward L,Richard R. Hardy,Tadamitsu Kishimoto +8 more
TL;DR: The study showed that Fc epsilon R is a B cell-specific differentiation marker, the expression of which is restricted to a defined stage of B cell differentiation.