Journal ArticleDOI
Molecular structure of human lymphocyte receptor for immunoglobulin E
Hitoshi Kikutani,S. Inui,Ryoichi Sato,Barsumian Edward L,Hajime Owaki,Katsuhiko Yamasaki,Tsuneyasu Kaisho,Naoto Uchibayashi,Richard R. Hardy,Toshio Hirano,Susumu Tsunasawa,Fumio Sakiyama,Masaki Suemura,Tadamitsu Kishimoto +13 more
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TLDR
A cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R) is isolated and shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc ePSilon R in endocytosis.About:
This article is published in Cell.The article was published on 1986-12-05. It has received 353 citations till now. The article focuses on the topics: T cell & B cell.read more
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Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.
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Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
TL;DR: Results indicate that BSF-1 and IFN-gamma as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses.
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Essential role of Stat6 in IL-4 signalling
Kiyoshi Takeda,Takashi Tanaka,Wei Shi,Makoto Matsumoto,Masashi Minami,Shin-ichiro Kashiwamura,Kenji Nakanishi,Nobuaki Yoshida,Tadamitsu Kishimoto,Shizuo Akira +9 more
TL;DR: It is concluded that Stat6 plays a central role in exerting IL-4-mediated biological responses, and production of Th2 cytokines from T cells as well as IgE and IgGl responses after nematode infection were profoundly reduced.
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The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
Tsutomu Kawabe,Tetsuji Naka,Kanji Yoshida,Takashi Tanaka,Hiroshi Fujiwara,Sachiko Suematsu,Nobuaki Yoshida,Tadamitsu Kishimoto,Hitoshi Kikutani +8 more
TL;DR: It is suggested that CD40 is essential for T cell-dependent immunoglobulin class switching and germinal center formation, but not for in vivo Tcell-dependent IgM responses and T cell -independent antibody responses.
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Interleukin-6: from basic science to medicine--40 years in immunology.
TL;DR: This essay summarizes the 40 years of research in immunology that revealed the framework of cytokine signaling, including identification of the IL-6 receptor, gp130, NF-IL6, STAT3, and SOCS-1, but also led to the development of a new therapy for chronic inflammatory diseases.
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
TL;DR: A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised and its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures.
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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
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A new method for sequencing DNA
Allan M. Maxam,Walter Gilbert +1 more
TL;DR: Reactions that cleave DNA preferentially at guanines, at adenines,At cytosines and thymines equally, and at cytosine alone are described.
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Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
TL;DR: In this paper, a simple and efficient method for synthesizing pure single stranded RNAs of virtually any structure is described, based on the unusually specific RNA synthesis by bacteriophage SP6 RNA polymerase which initiates transcription exclusively at an SP6 promoter.