S
Schunack Walter G
Researcher at Free University of Berlin
Publications - 28
Citations - 2013
Schunack Walter G is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Histamine H3 receptor & Receptor. The author has an hindex of 11, co-authored 28 publications receiving 1974 citations. Previous affiliations of Schunack Walter G include University of Mainz & French Institute of Health and Medical Research.
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Journal Article
International Union of Pharmacology. XIII. Classification of Histamine Receptors
Stephen J. Hill,Charon Robin Ganellin,Henk Timmerman,J C Schwartz,Nigel P. Shankley,J. M. Young,Schunack Walter G,Roberto Levi,Helmut L. Haas +8 more
TL;DR: The classification of histamine receptors has to date been based on rigorous classical pharmacological analysis, and as yet, the classification of the three histamines receptors that have been defined by this process have not been added to because of lack of evidence.
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High constitutive activity of native H3 receptors regulates histamine neurons in brain.
S. Morisset,A. Rouleau,Xavier Ligneau,Florence Gbahou,J. Tardivel-Lacombe,Holger Stark,Schunack Walter G,Charon Robin Ganellin,J C Schwartz,J.M. Arrang +9 more
TL;DR: It is shown that constitutive activity of native H3 receptors is present in rodent brain and that it controls histaminergic neuron activity in vivo, and inverse agonists may find therapeutic applications, even in the case of diseases involving non-mutated receptors expressed at normal levels.
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Protean agonism at histamine H3 receptors in vitro and in vivo
Florence Gbahou,A. Rouleau,S. Morisset,Régis Parmentier,Sylvain Crochet,Jian-Sheng Lin,Xavier Ligneau,J. Tardivel-Lacombe,Holger Stark,Schunack Walter G,C. Robin Ganellin,J C Schwartz,Jean-Michel Arrang +12 more
TL;DR: Protean agonism demonstrates the existence of ligand-directed active states LR* different from, and competing with, constitutively active states R* of GPCRs, and defines a pharmacological entity with important therapeutic implications.
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Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I]iodinated probes
Martial Ruat,Elisabeth Traiffort,M.L. Bouthenet,Jean-Charles Schwartz,J. Hirschfeld,Armin Buschauer,Schunack Walter G +6 more
TL;DR: A photoaffinity probe derived from 125I-APT was covalently incorporated in several peptides, among which the labeling of two peptides of 59 and 32 kDa was prevented by H2 antagonists, suggesting that they correspond to H2-receptor binding peptides or proteolysis products of the latter.
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beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.
TL;DR: It is concluded that the affinity of beta-carboline-3-carboxylates to the benzodiazepine receptor is profoundly dependent on molecular size, as well as hydrophobic and electronic parameters of the ester alcohol component.