W
Walter Schunack
Researcher at Free University of Berlin
Publications - 279
Citations - 5749
Walter Schunack is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Histamine H3 receptor & Histamine. The author has an hindex of 37, co-authored 279 publications receiving 5626 citations. Previous affiliations of Walter Schunack include University of Florence.
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Journal ArticleDOI
Highly potent and selective ligands for histamine H3-receptors.
J.M. Arrang,Monique Garbarg,J. C. Lancelot,J. M. Lecomte,Hélène Pollard,M. Robba,Walter Schunack,J C Schwartz +7 more
TL;DR: New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues.
Journal Article
Neurochemical and Behavioral Effects of Ciproxifan, A Potent Histamine H3-Receptor Antagonist
Xavier Ligneau,Jian-Sheng Lin,G. Vanni-Mercier,Michel Jouvet,J. L. Muir,Charon Robin Ganellin,Holger Stark,Sigurd Elz,Walter Schunack,J.-C. Schwartz +9 more
TL;DR: Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
Journal ArticleDOI
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.
Xavier Ligneau,Perrin David,Laurent Landais,J.-C. Camelin,Thierry Calmels,Isabelle Berrebi-Bertrand,Jeanne-Marie Lecomte,Régis Parmentier,Christelle Anaclet,Jian-Sheng Lin,Valerie Bertaina-Anglade,C. Drieu la Rochelle,F. d'Aniello,A. Rouleau,Florence Gbahou,J.M. Arrang,Charon Robin Ganellin,Holger Stark,Walter Schunack,J C Schwartz +19 more
TL;DR: Preclinical data suggest that BF2.649 is a valuable drug candidate to be developed in wakefulness or memory deficits and other cognitive disorders.
Journal ArticleDOI
Distinct pharmacology of rat and human histamine H3 receptors: role of two amino acids in the third transmembrane domain
Xavier Ligneau,S. Morisset,J. Tardivel-Lacombe,Florence Gbahou,Charon Robin Ganellin,Holger Stark,Walter Schunack,J.-C. Schwartz,J.M. Arrang +8 more
TL;DR: Starting from the sequence of the human histamine H3 receptor (hH3R) cDNA, the corresponding rat cDNA is cloned and two residues appear to be responsible for the distinct pharmacology of the H3R in the two species.
Journal Article
[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors.
Xavier Ligneau,Monique Garbarg,Marisa Vizuete,Jorge Diaz,K. Purand,Holger Stark,Walter Schunack,J.-C. Schwartz +7 more
TL;DR: The heterogenous distribution of H3 receptors with high labeling of anterior cerebral cortex, ventral striatum and other limbic areas was confirmed and a clearly distinguishable laminated pattern of labeling was evidenced in the cerebral cortex and hippocampal formation, which should be useful for sensitive assay and localization of the H3 receptor.