S Sandra Loerakker

TL;DR: A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals, which led to a clear understanding on two damage mechanisms associated with the development of DTI.

TL;DR: The results imply that deformation, ischemia, and reperfusion all contribute to the damage process during prolonged loading, although their importance varies with time.

TL;DR: The hypothesis that integration of a computationally inspired heart valve design into TE methodologies could guide tissue remodeling toward long-term functionality in tissue-engineered heart valves (TEHVs) is tested and suggests the relevance of an integrated in silico, in vitro, and in vivo bioengineering approach as a basis for the safe and efficient clinical translation of TEHVs.

TL;DR: It is shown that there is a reproducible monotonic increase in damage with increasing maximum shear strain once a strain threshold has been exceeded, confirming that tissue deformation per se is important in the aetiology of deep tissue injury.

TL;DR: An unmet clinical need remains for valve replacements with regenerative, remodelling and growth potential, and next-generation tissue-engineered heart valves (TEHVs) are a promising therapeutic option for patients with valvular heart disease.