Valentina Lintas

TL;DR: A fibrous valvular scaffold is designed, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix and offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures.

TL;DR: The hypothesis that integration of a computationally inspired heart valve design into TE methodologies could guide tissue remodeling toward long-term functionality in tissue-engineered heart valves (TEHVs) is tested and suggests the relevance of an integrated in silico, in vitro, and in vivo bioengineering approach as a basis for the safe and efficient clinical translation of TEHVs.

TL;DR: An unmet clinical need remains for valve replacements with regenerative, remodelling and growth potential, and next-generation tissue-engineered heart valves (TEHVs) are a promising therapeutic option for patients with valvular heart disease.

TL;DR: This study demonstrates the principal feasibility of clinically relevant hTEM to manufacture hTESVs for TPVR, and describes the in vitro development of human cell-derived TEM and their application as tissue-engineered sinus valves, endowed with Valsalva sinuses for TP VR.

TL;DR: Comparison of suture retention and mode I crack opening tests reveals a linear correlation between break starting strength and tearing energy, which suggests that the defect created by the needle and the load applied by the suture thread lead to a fracture mechanics problem, which dominates the initiation of failure.