S. Vicky Tsoni

TL;DR: It is shown that dectin-1–Syk–CARD9 signaling induced DC maturation and the secretion of proinflammatory cytokines, including IL-6, tumor necrosis factor and IL-23, but little IL-12.

TL;DR: It is shown that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans, and a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses is established.

TL;DR: These findings establish the first example of Syk‐ and MyD88‐coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents.

TL;DR: The characterization of dectin‐1 has revealed some of the processes involved in β‐glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of β‐ glucans in immunity and disease.

TL;DR: A soluble chimeric form of the major mammalian β-glucan receptor, Dectin-1, is developed and its application for the detection and characterisation of soluble and insoluble β-Glucans, including fungal particles, is demonstrated using ELISA, flow cytometric and fluorescence-based microscopy assays.