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David L. Williams
Researcher at East Tennessee State University James H. Quillen College of Medicine
Publications - 113
Citations - 11454
David L. Williams is an academic researcher from East Tennessee State University James H. Quillen College of Medicine. The author has contributed to research in topics: Glucan & Innate immune system. The author has an hindex of 52, co-authored 111 publications receiving 10569 citations. Previous affiliations of David L. Williams include Tulane University & East Tennessee State University.
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Journal ArticleDOI
Dectin-1 Mediates the Biological Effects of β-Glucans
Gordon D. Brown,Jurgen Herre,David L. Williams,Janet A. Willment,Andrew S J Marshall,Siamon Gordon +5 more
TL;DR: It is shown that Dectin-1 mediates the production of TNF-α in response to zymosan and live fungal pathogens, an activity that occurs at the cell surface and requires the cytoplasmic tail and immunoreceptor tyrosine activation motif of Dect in addition to Toll-like receptor (TLR)-2 and Myd88.
Journal ArticleDOI
Dectin-1 Is A Major β-Glucan Receptor On Macrophages
Gordon D. Brown,Philip R. Taylor,Delyth M. Reid,Janet A. Willment,David L. Williams,Luisa Martinez-Pomares,Simon Y. C. Wong,Siamon Gordon +7 more
TL;DR: Dectin-1 is defined as the leukocyte β-glucan receptor, first described over 50 years ago, and resolves the long-standing controversy regarding the identity of this important molecule, which is identified as a new target for examining the immunomodulatory properties of β- glucans for therapeutic drug design.
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Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins
Neil C. Rogers,Emma Slack,Alexander D. Edwards,Martijn A. Nolte,Oliver Schulz,Edina Schweighoffer,David L. Williams,Siamon Gordon,Victor L. J. Tybulewicz,Gordon D. Brown,Caetano Reis e Sousa +10 more
TL;DR: It is demonstrated that the beta-glucan receptor Dectin-1, a yeast binding C type lectin known to synergize with TLR2 to induce TNF alpha and IL-12, can also promote synthesis of IL-2 andIL-10 through phosphorylation of the membrane proximal tyrosine in the cytoplasmic domain and recruitment of Syk kinase.
Journal ArticleDOI
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Chad Steele,Rekha R. Rapaka,Allison E. Metz,Shannon M. Pop,David L. Williams,Siamon Gordon,Jay K. Kolls,Gordon D. Brown +7 more
TL;DR: Data show that dectin-1 is centrally required for the generation of alveolar macrophage proinflammatory responses to A. fumigatus and provides the first in vivo evidence for the role of dectIn-1 in fungal innate defense.
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Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
Kevin M. Dennehy,Gerben Ferwerda,Inês Faro-Trindade,Elwira Pyz,Janet A. Willment,Philip R. Taylor,Philip R. Taylor,Ann M. Kerrigan,S. Vicky Tsoni,Siamon Gordon,Friederike Meyer-Wentrup,Gosse J. Adema,Bart Jan Kullberg,Edina Schweighoffer,Victor L. J. Tybulewicz,Héctor M. Mora-Montes,Neil A. R. Gow,David L. Williams,Mihai G. Netea,Gordon D. Brown +19 more
TL;DR: These findings establish the first example of Syk‐ and MyD88‐coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents.