K
Ken Haynes
Researcher at University of Exeter
Publications - 80
Citations - 7169
Ken Haynes is an academic researcher from University of Exeter. The author has contributed to research in topics: Candida glabrata & Candida albicans. The author has an hindex of 37, co-authored 79 publications receiving 6697 citations. Previous affiliations of Ken Haynes include University of Oxford & Imperial College London.
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Journal ArticleDOI
Dectin-1 is required for beta-glucan recognition and control of fungal infection.
Philip R. Taylor,S. Vicky Tsoni,Janet A. Willment,Kevin M. Dennehy,Marcela Rosas,Helen Findon,Ken Haynes,Chad Steele,Marina Botto,Siamon Gordon,Gordon D. Brown +10 more
TL;DR: It is shown that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans, and a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses is established.
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Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals
TL;DR: Atypical oral Candida isolates recovered from 60 HIV-infected and three HIV-negative individuals strongly suggest that they constitute a novel species within the genus Candida for which the name Candida dubliniensis is proposed.
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Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence
Markus Schrettl,Elaine Bignell,Claudia Kragl,Chistoph Joechl,Thomas R. Rogers,Herbert N. Arst,Ken Haynes,Hubertus Haas +7 more
TL;DR: It is shown that Aspergillus fumigatus does not have specific mechanisms for the utilization of host iron sources, but it does have functional siderophore-assisted iron mobilization and reductive iron assimilation systems, both of which are induced upon iron deprivation.
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Fungal Adenylyl Cyclase Integrates CO2 Sensing with cAMP Signaling and Virulence
Torsten Klengel,Wei-Jun Liang,James Chaloupka,Claudia Ruoff,Klaus Schröppel,Julian R. Naglik,Sabine E. Eckert,Estelle Gewiss Mogensen,Ken Haynes,Mick F. Tuite,Lonny R. Levin,Jochen Buck,Fritz A. Mühlschlegel +12 more
TL;DR: It is demonstrated that physiological concentrations of CO2/HCO3- induce filamentation in C. albicans by direct stimulation of cyclase activity and revealed CO2 sensing to be an important mediator of fungal pathogenesis.
Journal ArticleDOI
Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.
Markus Schrettl,Elaine Bignell,Claudia Kragl,Yasmin Sabiha,Omar Loss,Martin Eisendle,Anja Wallner,Herbert N. Arst,Ken Haynes,Hubertus Haas +9 more
TL;DR: In this article, the authors delineate pathways of intra-and extracellular siderophore biosynthesis and show that A. fumigatus synthesizes a developmentally regulated fourth siderore, termed hydroxyferricrocin, employed for conidial iron storage.