S
Sabine Steffens
Researcher at Ludwig Maximilian University of Munich
Publications - 127
Citations - 11173
Sabine Steffens is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammation & Cannabinoid receptor. The author has an hindex of 47, co-authored 115 publications receiving 9533 citations. Previous affiliations of Sabine Steffens include Children's Hospital of Philadelphia & University of Düsseldorf.
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Journal ArticleDOI
Inflammation and atherosclerosis.
Sabine Steffens,François Mach +1 more
TL;DR: New insights are provided on inflammatory processes involved in atherosclerosis development provide important links between risk factors and the mechanisms of atherogenesis and a major challenge for future research is to implement these new insights in order to improve strategies for prediction, prevention and treatment of cardiovascular events.
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Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
Michael Horckmans,Larisa Ring,Johan Duchene,Donato Santovito,Donato Santovito,Maximilian J. Schloss,Maik Drechsler,Christian Weber,Oliver Soehnlein,Sabine Steffens +9 more
TL;DR: Neutrophils are crucially involved in cardiac repair after MI by polarizing macrophages towards a reparative phenotype, andTherapeutic strategies to reduce acute neutrophil-driven inflammation after MI should be carefully balanced as they might interfere with the healing response and cardiac remodelling.
Journal ArticleDOI
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
Sabine Steffens,Niels R. Veillard,Claire Arnaud,Graziano Pelli,Fabienne Burger,Christian Staub,Andreas Zimmer,Jean-Louis Frossard,François Mach +8 more
TL;DR: Oral treatment with a low dose of THC inhibits atherosclerosis progression in the apolipoprotein E knockout mouse model through pleiotropic immunomodulatory effects on lymphoid and myeloid cells, demonstrating that THC or cannabinoids with activity at the CB2 receptor may be valuable targets for treating Atherosclerosis.
Journal ArticleDOI
Neutrophils as protagonists and targets in chronic inflammation
Oliver Soehnlein,Sabine Steffens,Andrés Hidalgo,Andrés Hidalgo,Christian Weber,Christian Weber +5 more
TL;DR: This Review aims to summarize the current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues.
Journal ArticleDOI
Biomechanical factors in atherosclerosis: mechanisms and clinical implications.
Brenda R. Kwak,Magnus Bäck,Marie-Luce Bochaton-Piallat,Giuseppina Caligiuri,Mat J.A.P. Daemen,Peter F. Davies,Imo E. Hoefer,Paul Holvoet,Hanjoong Jo,Rob Krams,Stephanie Lehoux,Claudia Monaco,Sabine Steffens,Renu Virmani,Christian Weber,Jolanda J. Wentzel,Paul C. Evans +16 more
TL;DR: The current 'state of the art' on the interface between mechanical forces and atherosclerotic plaque biology is summarized and potential clinical applications and key questions for future research are identified.