I
Imo E. Hoefer
Researcher at Utrecht University
Publications - 233
Citations - 8796
Imo E. Hoefer is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Arteriogenesis. The author has an hindex of 44, co-authored 207 publications receiving 7514 citations. Previous affiliations of Imo E. Hoefer include University Medical Center Utrecht.
Papers
More filters
Journal ArticleDOI
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.
Leo Timmers,Sai Kiang Lim,Fatih Arslan,Jeffrey S. Armstrong,Imo E. Hoefer,Pieter A. Doevendans,Jan J. Piek,Reida El Oakley,Andre Choo,Chuen Neng Lee,Gerard Pasterkamp,Dominique P.V. de Kleijn +11 more
TL;DR: The data identify human MSC-CM as a promising therapeutic option to reduce myocardial infarct size in patients with acute MI and suggest that the use of stem cell secretions could extend the applicability of stem cells for therapeutic purposes.
Journal ArticleDOI
Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury.
Leo Timmers,José P.S. Henriques,Dominique P.V. de Kleijn,J. Hans DeVries,Hans Kemperman,Paul Steendijk,Cees W.J. Verlaan,Marjolein Kerver,Jan J. Piek,Pieter A. Doevendans,Gerard Pasterkamp,Imo E. Hoefer +11 more
TL;DR: These data identify exenatide as a potentially effective compound to reduce infarct size in adjunction to reperfusion therapy in patients with acute MI.
Journal ArticleDOI
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction
Leo Timmers,Sai Kiang Lim,Imo E. Hoefer,Fatih Arslan,Ruenn Chai Lai,Angelique A M Van Oorschot,Marie-José Goumans,Chaylendra Strijder,Sui Kwan Sze,Andree Choo,Jan J. Piek,Pieter A. Doevendans,Gerard Pasterkamp,Dominique P.V. de Kleijn +13 more
TL;DR: Intravenous MSC-CM treatment after myocardial infarction increases capillary density and preserves cardiac function, probably by increasing myocardia perfusion.
Journal ArticleDOI
Biomechanical factors in atherosclerosis: mechanisms and clinical implications.
Brenda R. Kwak,Magnus Bäck,Marie-Luce Bochaton-Piallat,Giuseppina Caligiuri,Mat J.A.P. Daemen,Peter F. Davies,Imo E. Hoefer,Paul Holvoet,Hanjoong Jo,Rob Krams,Stephanie Lehoux,Claudia Monaco,Sabine Steffens,Renu Virmani,Christian Weber,Jolanda J. Wentzel,Paul C. Evans +16 more
TL;DR: The current 'state of the art' on the interface between mechanical forces and atherosclerotic plaque biology is summarized and potential clinical applications and key questions for future research are identified.
Journal ArticleDOI
Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody
Fatih Arslan,Mirjam B. Smeets,Luke A. J. O'Neill,Brian Keogh,Peter McGuirk,Leo Timmers,Claudia Tersteeg,Imo E. Hoefer,Pieter A. Doevendans,Gerard Pasterkamp,Dominique P.V. de Kleijn +10 more
TL;DR: Monoclonal anti-TLR2 antibody is a potential candidate as an adjunctive for reperfusion therapy in patients with myocardial infarction and reduces infarct size and preserves cardiac function and geometry.