HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
Monica Fedele,Rosa Visone,Ivana De Martino,Giancarlo Troncone,Dario Palmieri,Sabrina Battista,Andrea Ciarmiello,Pierlorenzo Pallante,Claudio Arra,Rosa Marina Melillo,Kristian Helin,Carlo M. Croce,Alfredo Fusco +12 more
TLDR
It is shown that HMGA2 interacts with pRB and induces E2F1 activity in mouse pituitary adenomas by displacing HDAC1 from the pRB/E2F 1 complex-a process that results in E2f1 acetylation.About:
This article is published in Cancer Cell.The article was published on 2006-06-13 and is currently open access. It has received 239 citations till now. The article focuses on the topics: HMGA2 & Transgene.read more
Citations
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Journal ArticleDOI
Roles of HMGA proteins in cancer.
Alfredo Fusco,Monica Fedele +1 more
TL;DR: The role of the high mobility group A (HMGA) proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins are focused on.
Journal ArticleDOI
Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
TL;DR: Hmga2 promotes fetal and young-adult stem cell self-renewal by decreasing p16(Ink4a)/p19(Arf) expression, which is partly caused by the increasing expression of let-7b microRNA,which is known to target HMGA2.
Journal ArticleDOI
Acromegaly pathogenesis and treatment
TL;DR: Effective control of GH and IGF1 hypersecretion and ablation or stabilization of the pituitary tumor mass lead to improved comorbidities and lowering of mortality rates for this hormonal disorder.
Journal ArticleDOI
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.
Masashi Narita,Masako Narita,Valery Krizhanovsky,Sabrina Nuñez,Agustin Chicas,Stephen Hearn,Michael P. Myers,Scott W. Lowe,Scott W. Lowe +8 more
TL;DR: This work shows that the High-Mobility Group A (HMGA) proteins accumulate on the chromatin of senescent fibroblasts and are essential structural components of SAHFs, and implies that HMGA proteins also act in tumor suppressor networks.
Journal ArticleDOI
Pathogenesis of pituitary tumors.
TL;DR: Understanding subcellular mechanisms that underlie pituitary tumorigenesis will enable development of tumor aggression markers as well as novel targeted therapies.
References
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Journal ArticleDOI
Effects of an Rb mutation in the mouse
Tyler Jacks,Amin Fazeli,Earlene M. Schmitt,Roderick T. Bronson,Margaret A. Goodell,Robert A. Weinberg +5 more
TL;DR: A mouse strain has been constructed in which one allele of Rb is disrupted, and heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent.
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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.
TL;DR: It is shown that recruitment of the p160 class of coactivators is sufficient for gene activation and for the growth stimulatory actions of estrogen in breast cancer supporting a model in which ER cofactors play unique roles in estrogen signaling.
Journal ArticleDOI
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
Laura Magnaghi-Jaulin,R Groisman,Irina Naguibneva,Philippe Robin,S. Lorain,J. P. Le Villain,Frédéric Troalen,Didier Trouche,Annick Harel-Bellan +8 more
TL;DR: It is shown here that the histone deacetylase HDAC1 physically interacts and cooperates with Rb, and that the Rb/HDAC1 complex is a key element in the control of cell proliferation and differentiation and that it is a likely target for transforming viruses.
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E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
Seth J. Field,Seth J. Field,Fong-Ying Tsai,Fong-Ying Tsai,Frank C. Kuo,Ana M. Zubiaga,Ana M. Zubiaga,William G. Kaelin,David M. Livingston,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Michael E. Greenberg,Michael E. Greenberg +13 more
TL;DR: It is suggested that while certain members of the E2F family may positively regulate cell cycle progression, E1F-1 functions to regulate apoptosis and to suppress cell proliferation.
Journal ArticleDOI
Regulation of E2F1 activity by acetylation
TL;DR: It is suggested that acetylation stimulates the functions of the non‐RB bound ‘free’ form of E2F1, and it is found that the RB‐associated histone de acetylase can deacetylate E2f1.