S
Sabrina Kuespert
Researcher at University of Regensburg
Publications - 11
Citations - 340
Sabrina Kuespert is an academic researcher from University of Regensburg. The author has contributed to research in topics: Trabecular meshwork & CTGF. The author has an hindex of 6, co-authored 9 publications receiving 254 citations. Previous affiliations of Sabrina Kuespert include University Hospital Regensburg.
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Journal ArticleDOI
Connective Tissue Growth Factor Causes Glaucoma by Modifying the Actin Cytoskeleton of the Trabecular Meshwork
Benjamin Junglas,Sabrina Kuespert,Amin A. Seleem,Tobias Struller,Sabrina Ullmann,Michael R. Bösl,Anja K. Bosserhoff,Josef Köstler,Ralf Wagner,Ernst R. Tamm,Rudolf Fuchshofer +10 more
TL;DR: Connective tissue growth factor overexpression in the mouse eye increases intraocular pressure and leads to optic nerve damage, and the effects of CTGF on IOP appear to be caused by a modification of the TM actin cytoskeleton.
Journal ArticleDOI
Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice.
Leonie Herrnberger,Roswitha Seitz,Sabrina Kuespert,Michael R. Bösl,Rudolf Fuchshofer,Ernst R. Tamm +5 more
TL;DR: Plasmalemmal vesicle-associated protein (PLVAP, PV-1) is specifically expressed in endothelial cells in which it localizes to diaphragms of fenestrae, caveolae, and transendothelial channels, and its function was learned by generating mutant mice that lack PLVAP.
Journal ArticleDOI
The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis.
Sebastian Peters,Eva Zitzelsperger,Sabrina Kuespert,Sabine Iberl,Rosmarie Heydn,Siw Johannesen,Susanne Petri,Ludwig Aigner,Dietmar Rudolf Thal,Andreas Hermann,Jochen H. Weishaupt,Tim-Henrik Bruun,Ulrich Bogdahn +12 more
TL;DR: There is an upregulated TGF-β system in specific tissues in ALS that might lead to a “neurotoxic” immune response, promoting disease progression and neurodegeneration, and this system may represent a promising target in treatment of ALS patients.
Journal ArticleDOI
The regulation of connective tissue growth factor expression influences the viability of human trabecular meshwork cells
TL;DR: The beneficial effect of CTGF for viability of TM cells is likely associated with the effects on increased ECM synthesis and higher contractility of the TM, thereby contributing to reduced aqueous humour outflow facility causing increased intraocular pressure.
Journal ArticleDOI
Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2—A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling
Sabrina Kuespert,Rosmarie Heydn,Sebastian Peters,Eva Wirkert,Anne-Louise Meyer,Anne-Louise Meyer,Mareile Siebörger,Siw Johannesen,Ludwig Aigner,Ulrich Bogdahn,Ulrich Bogdahn,Tim-Henrik Bruun +11 more
TL;DR: It is shown that TGFBR2 mRNA as a single gene target for NVP-13 responds well, and that it bears great potential to be safe and efficient in TGFβ signaling related disorders.